Dendrobium officinale nimodipine combination medicine for resisting hypertension and apoplexia, and preparation method thereof

Dendrobium officinale, anti-hypertensive technology, applied in the field of preparation of anti-hypertensive stroke drugs, to achieve the effect of preventing hypertensive stroke, rapid blood pressure, relieving and lasting blood pressure

Active Publication Date: 2010-09-29
ZHEJIANG TIANHUANG MEDICINAL PLANT PHARMA
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the fact that the water extract of Dendrobium officinale is still a new application in the prevention and treatment of high blood pressure or stroke, so far, no one has any public information showing that researchers have conducted research on the combined effect of Dendrobium officinale and nimodipine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0032] 1. Materials and methods for animal experiments:

[0033] 1. Water extract of Dendrobium candidum: provided by Zhejiang Tianhuang Pharmaceutical Co., Ltd.

[0034] 2. Hypertensive animal model rats: use stroke-prone spontaneously hypertensive rats (SHR-sp). SHR-sp is similar to severe hypertension in the human body. The disease progresses quickly and is prone to stroke. SHR-sp is obtained from the offspring of SHR who died of stroke through close relatives selection and mating. Stroke can occur within 9 to 13 months without additional inducement (normal diet feeding), and the incidence can be as high as 90%. The pathological changes in the occurrence and development of hypertension and stroke are similar to those of humans, and can better reflect the effects of drugs (in humans). The above model was provided by Shanghai Animal Center of Chinese Academy of Sciences. The animals in each group started the experiment at 10 weeks of age and used both sexes. Clean grade (SPF) ...

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Abstract

The invention relates to the preparation of medicine for resisting hypertension and apoplexia, aiming at providing a dendrobium officinale nimodipine combination medicine for resisting hypertension and apoplexia, and a preparation method thereof. The dendrobium officinale nimodipine combination medicine has the effective components comprising dendrobium officinale water extract and nimodipine which have the mass ratio of 1.0-4.0: 0.12-0.24. The invention also provides extract, granules, tablets, capsules and pharmaceutical intermediate which are based on the medicine, and a preparation method thereof. The invention compares the use of the combination medicine and the single use of the dendrobium officinale or the nimodipine, and the combination medicine not only can more rapidly reduce blood pressure, but also can better reduce the death rate and prolong the survival time. When being used as the medicine with special usage to be applied, the combination medicine can alleviate and reduce the blood pressure of hypertensive patients for a long time, delays the development of hypertensive cerebral vascular damage, and has important significance for preventing hypertension and apoplexia of human beings and reducing cripple and fatality rate caused by hypertension.

Description

Technical field [0001] The invention relates to the preparation of antihypertensive stroke drugs, in particular to a combination drug of dendrobium candidum and nimodipine for antihypertensive stroke and a preparation method thereof. Background technique [0002] Hypertension is a common high incidence, and the prevalence is increasing year by year. At present, there are about 200 million patients with hypertension in my country. With the acceleration of the pace of life, changes in dietary structure, lack of exercise, the age of onset is advanced year by year, and the incidence is further rising. As the disease progresses, hypertension often causes damage to important vital organs such as the brain, heart, and kidneys, causing functional changes and organic damage, and even disability and death. Stroke is one of severe hypertensive organ damage. Among the current Chinese and Western medicines for the prevention and treatment of hypertension, while controlling blood pressure, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61K9/16A61K9/48A61K9/20A61K9/06A61P9/12A61P9/10A61K31/4422
Inventor 陈立钻楼正家吴人照杨兵勋张旭峰杨芳亮夏克中沈春香陈午兵王增陈宇郑纯威李端阳
Owner ZHEJIANG TIANHUANG MEDICINAL PLANT PHARMA
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