Cyclic hexapeptide antibacterial compound

Abstract

The invention provides a novel cyclic hexapeptide antibacterial compound yanglingmycins, belonging to the technical field of medicaments. The compound in the invention has a structural formula shown in the specification. The amino acid composition of the cyclic hexapeptide antibacterial compound comprises valine and other unconventional amino acids, such as 2-methylamino propionic acid, piperazin-3-carboxylic acid and 6-chloro-3alpha-hydroxy-1, 2, 3, 3alpha, 8, 8alpha-hexyhydro [2, 3-pyrrolo] indol-2-carboxylic acid, wherein each amino acid is in an L configuration or a D configuration. The compound in the invention can strongly inhibit many kinds of gram positive bacteria such as bacillus cereus, bacillus subtilis, staphylococcus aureus and methicillin resistant staphylococcus aureus.

Description

Technical field: The invention relates to the technical field of medicines, in particular to a novel cyclic hexapeptide antibacterial compound yanglingmycins extracted and separated from soil actinomycete fermentation broth. Background technique: Screening biologically active substances from microbial secondary metabolites is an important approach in the research and development of new drugs. So far, there are more than 50,000 microbial secondary metabolites whose structures have been clarified, including more than 22,000 compounds with clear biological activities. Since Wakesman isolated streptomycin from the culture solution of Streptomyces griseus, soil actinomycetes have become the main source of antibiotics, and the amount of antibiotics produced by them accounts for 47% of all microbial active metabolites. Yanglingmycins is a new class of cyclic hexapeptide antibacterial compounds produced by the metabolism of Streptomyces alboflavus No.313 isolated from the soil of ...

AI Technical Summary

Problems solved by technology

The cyclic hexapeptide antibiotics similar to this structure have been found so far, including himastatin and chloptosin, but the latter two are dimers formed by two cyclic hexapeptides, and there are also differences in amino acid composition

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