Method for preparing degradable polyampholyte microgel

A polyampholyte and microgel technology, applied in particle and sedimentation analysis, instruments, analytical materials, etc., can solve the problems of large particle size, low solid content and small specific surface area of ​​the product

Inactive Publication Date: 2011-11-09
TAIYUAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] At present, the methods for preparing polyampholyte microgels include solution polymerization, soap-free emulsion polymerization, dispersion polymerization, etc. Most of these methods have low monomer aqueous solution concentration, low solid content, large particle size, small specific surface area, Problems such as slow swelling rate

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  • Method for preparing degradable polyampholyte microgel
  • Method for preparing degradable polyampholyte microgel
  • Method for preparing degradable polyampholyte microgel

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Embodiment Construction

[0135] The present invention will be further described below in conjunction with accompanying drawing:

[0136] figure 1 As shown, it is the preparation process flow chart, which must be carried out strictly according to the process parameters and operated in sequence.

[0137] During preparation, the chemical substances used are determined within pre-set ranges in grams, milliliters, centimeters 3 It is a unit of measurement, and when it is produced industrially, it is expressed in kilograms, liters, or meters 3 is the unit of measurement.

[0138] Electric heating dishes, water bathtubs, four-neck flasks, three-neck flasks, nitrogen tubes, dropping funnels, stirrers, outlet pipes, beakers, suction flasks, Buchner funnels, vacuum ovens, quartz product boats, containers, Filter paper, etc. should be kept clean, and no impurities should be allowed to intervene to prevent by-products.

[0139] The cross-linking agent N,N'-bis(acryloyl)cystamine is degradable.

[0140] The i...

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Abstract

The invention relates to a method for preparing degradable polyampholyte microgel, which comprises the following steps of: preparing reversed phase microemulsion, aqueous phase solution and oil phase solution; taking an oil phase as mother solution to prepare transparent oil-in-water reversed phase microemulsion showing slight blue light; adding initiating agents aqueous solution of ammonium persulfate and aqueous solution of N,N,N',N'-tetramethyl quadrol into the oil-in-water reversed phase microemulsion for polymerization reaction under the conditions of electric heating, water bath, nitrogenization and stirring so as to prepare polyampholyte microgel emulsion; and performing demulsification and precipitation by acetone, washing, filtration, dialysis, centrifugal separation and vacuum drying to prepare loosened meshed ivory polyampholyte microgel pulverulent particles, wherein the average diameter of dry spherical particles is 80 nanometers, the specific surface area is 48.478 / m<2>.g<-1>, the average diameter of meshes is 30.23 nanometers, and the hydromechanical diameter of the particles at the position of isoelectric points is 105.7 nanometers. The preparation method has the advantages of high yield up to 99.5 percent, and good product purity of 99.6 percent.

Description

technical field [0001] The invention relates to a preparation method of degradable polyampholyte microgel, which belongs to the technical field of preparation methods of organic polymer colloidal particles. Background technique [0002] Microgel is a kind of intramolecular cross-linked polymer colloid particles, its internal structure is between branched chain polymers and macroscopic network cross-linked polymers, and it is usually dispersed and swollen in a solvent in a colloidal state. Between 50-500nm, the swollen microgel can form a colloidal dispersion in the solvent. The microgel has small particle size, large specific surface area, fast response speed, good dimensional stability, high degree of hydration, and easy function It has a controllable structure, can swell in water without dissolving, has good biocompatibility, and can be used in protein adsorption, separation, immobilized enzymes, drug controlled release systems, tissue engineering and other fields. [000...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/06C08F220/34C08F222/38C08F2/32C08F4/40C08F2/01G01N15/00G01N15/02
Inventor 申迎华李晓琴树学峰张林香邱丽郝晓刚
Owner TAIYUAN UNIV OF TECH
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