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Levamlodipine compound medicinal preparation

A technology of levamlodipine and pharmaceutical preparations, applied in the pharmaceutical field, can solve the problems of patients with bradycardia and the like, and achieve the effects of reducing the dosage, good synergistic antihypertensive effect, and reducing adverse reactions

Inactive Publication Date: 2010-10-27
SHIHUIDA PHARMA GRP (JILIN) LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, β and α receptor blockers also have the disadvantages of β and α receptor blockers at the same time, which can cause bradycardia in patients, etc.

Method used

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  • Levamlodipine compound medicinal preparation
  • Levamlodipine compound medicinal preparation
  • Levamlodipine compound medicinal preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 13-17

[0042] The preparation of embodiment 13-17 compound capsule

[0043] The formula of table 4 embodiment 13-17 compound capsule

[0044]

[0045]

[0046] Preparation process: put levamlodipine besylate, β and α receptor blocker, and microcrystalline cellulose into a mortar, grind and mix evenly, pass through a 20-mesh sieve, and add an appropriate amount of 0.5% PVP-k30 ethanol solution to prepare The soft material is granulated through a 20-mesh sieve, ventilated and dried at 40°C, the dry granules are granulated with a 16-mesh sieve, added talcum powder, mixed evenly, and then packed into capsules.

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PUM

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Abstract

The invention discloses a levamlodipine compound medicinal composition, which comprises levamlodipine or a pharmaceutically acceptable salt thereof, and a beta-alpha receptor antagonist. The medicament combining the levamlodipine and the beta-alpha receptor antagonist is used for treating high blood pressure, has good synergetic blood pressure reducing function, can reduce the administration dosage of the levamlodipine and the beta-alpha receptor antagonist while achieving the same or better blood pressure reducing effect, and reduces adverse reaction caused by large-dosage single medicament. In addition, the beta-alpha receptor antagonist also can suppress reflex tachycardia caused by the levamlodipine.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular to a compound drug preparation of levamlodipine. Background technique [0002] In recent years, with the continuous improvement of people's living standards in our country and the change of dietary structure, the increase of life pressure, and the increase of the elderly population, the incidence of hypertension has gradually increased, and it will cause heart, brain, kidney, etc. It is closely related to the disorder of sugar and lipid metabolism and diabetes, which obviously reduces the quality of life of the patient, and even endangers the life of the patient in severe cases. However, a large number of international authoritative clinical studies on hypertension have shown that increasing the pressure reduction, actively and durably reducing the blood pressure of hypertensive patients to below 130 / 85 mmHg (the best should be below 120 / 80 mmHg), can Effectively reduce damage to target org...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K31/403A61K31/609A61K31/427A61P9/12
CPCA61K9/2054A61K31/427A61K31/403A61K31/4422A61K31/166A61P9/12
Inventor 杨彦玲薛传校张喜田李环宋森涛
Owner SHIHUIDA PHARMA GRP (JILIN) LTD
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