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Total effective extractive part of morinda officinalis, as well as preparation method and application thereof

A technology of effective parts, Morinda officinalis, applied in the field of total effective parts of Morinda officinalis extract

Inactive Publication Date: 2010-11-03
仇鑫 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no relevant literature records or research reports at home and abroad on the use of the total effective fraction extract of Morinda officinalis in products for the treatment of sleep apnea syndrome

Method used

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  • Total effective extractive part of morinda officinalis, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Preparation of Morinda officinalis Total Effective Parts Extract 1

[0050] Take 1000g of Morinda officinalis medicinal material, dry it and crush it to 10-100 mesh, extract it with 10L of water by heating and refluxing for 2 hours, extract 3 times in total, combine the extracts, and put them on the D941 macroporous weak base Anion exchange resin, eluted with water until the color of the eluent became lighter, collected the flow-through liquid and water eluate, concentrated and dried to obtain 103g of Morinda officinalis total polysaccharide; # Extract solvent oil 10L and reflux extract twice, each time for 2 hours, combine the extracts, concentrate under reduced pressure and recover solvent oil, the extract is mainly low polar components such as volatile oil, discard; the remaining dregs are finally washed with 70% ethanol (10L ) reflux extraction, the time is 1 hour, 3 times in total, the combined extracts are vacuum concentrated and dried to obtain 10 g of ...

Embodiment 2

[0051] Example 2 Preparation of Morinda officinalis Total Effective Parts Extract 2

[0052] Take 1000g of Morinda officinalis medicinal material, dry it and crush it to 10-100 meshes, extract it with 5L of water by heating and refluxing for 2 hours, extract 3 times in total, combine the extracts, and put them on the D301 macroporous weak base Anion exchange resin, eluted with water until the color of the eluent became lighter, collected the flow-through liquid and the water eluate, concentrated and dried to obtain 89g of total polysaccharides of Morinda officinalis officinalis; after water extraction, the dregs were extracted with 5L of petroleum ether under reflux 2 times, 2 hours each time, combine the extracts, concentrate under reduced pressure and recover petroleum ether, the extracts are mainly low polar components such as volatile oil, discard them; the remaining dregs are finally extracted with 40% ethanol (5L) under reflux, and the time is 1 hour, carried out 3 times...

Embodiment 3

[0053] Example 3 Preparation of Morinda officinalis Total Effective Parts Extract 3

[0054] Take 1000g of Morinda officinalis medicinal material, dry it and crush it to 10-100 mesh, extract it with 20L of water by heating and refluxing for 2 hours, extract 3 times in total, combine the extracts, and use 330 type weak base anion exchange Resin, eluted with water until the color of the eluent becomes lighter, collect the flow-through liquid and water eluate, concentrate and dry to obtain 114g of Morinda officinalis total polysaccharide; after water extraction, the dregs are extracted twice with 20L of hexane , each 2 hours, combined extracts, concentrated under reduced pressure and reclaimed hexane, the extracts were mainly low polar components such as volatile oil, discarded; the remaining dregs were finally refluxed with 95% ethanol (20L) for 1 hour, A total of 3 times were extracted, the combined extracts were vacuum concentrated and dried to obtain 36g of Morinda officinali...

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Abstract

The invention discloses a total effective part extractive of morinda officinalis, a preparation method and application thereof in medicaments for treating snoring, and the total effective part comprises the following components in percentage by weight: 50-90 percent of morinda officinalis total polysaccharide, 2-5 percent of morinda officinalis total anthraquinone, 5-30 percent of morinda officinalis total iridoids and the like. The preparation method comprises the following steps of: drying the morinda officinalis, and crushing into 10-100 meshes; heating with water for reflux extraction; processing the extract by using a weak base anion exchange resin column, collecting the cross-flow liquid and water eluent, and condensing and drying to obtain the total polysaccharide; carrying out reflux extraction on the dregs of decoction with petroleum ether or 6# extraction solvent oil or other organic solvents with polarity similar to that of the dregs, and removing low-polarity components, such as essential oil and the like; heating the residual dregs with ethanol water with a certain concentration for reflux extraction, and condensing the extract to prepare the total anthraquinone and total iridoids; and then merging the three components, and drying to obtain the total effective part extractive of morinda officinalis. The product of the invention is used for treating snoring (also called as Sleep apnea syndrome (SAS)), and has the advantages of quick and remarkable curative effect, no toxic or side effect, low price, convenient use and the like.

Description

technical field [0001] The invention relates to an extract of total effective parts of Morinda officinalis, a preparation method and application thereof, and belongs to the field of traditional Chinese medicine pharmacy. Background technique [0002] Snoring, also known as snoring, is a common sleep phenomenon. At present, most people think that it is commonplace and don’t take it seriously. Some people regard snoring as a sign of a good sleep. In fact, snoring is the enemy of health . One-third of a person's life is spent in sleep. Normal people breathe evenly during sleep, and the oxygen intake meets the needs of all parts of the body. While sleeping for 7 hours every night, people with apnea due to snoring are in an anaerobic inhalation state for 300-400 seconds, and the blood oxygen concentration is about 8-10% lower than the normal value, so night after night, year after year, Fragmented sleep significantly reduces oxygen intake, ischemia and hypoxia in important part...

Claims

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Application Information

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IPC IPC(8): A61K36/746A61P11/00A23L1/29A61K125/00A23L33/00
Inventor 仇鑫
Owner 仇鑫
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