Water-soluble amino-acid ester derivative of ginkgolide B

A technology of ginkgolide and amino acid ester is applied in the directions of drug combination, organic active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of poor water solubility of ginkgolide B, limited clinical application, etc.
CN101880286AInactive Publication Date: 2010-11-10BEIJING MEIBEITA DRUG RES
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING MEIBEITA DRUG RES
Publication Date
2010-11-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an amino-acid ester derivative of ginkgolide B shown as a formula I and pharmaceutical salts thereof, a medicinal composition taking the compounds as active ingredients, and application of the compounds and the medicinal composition in serving as medicaments for treating cardiovascular and cerebrovascular diseases. In the formula I, A1 and A2 is residues of H, glycyl, L-alanyl, L-leucyl, L-valyl, L-isoleucyl, or L-phenylaminoacyl and other amino acids; A1 is the same as or different from A2; and A1 and A2 cannot be H at the same time.
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Description

technical field

[0001] The present invention relates to novel derivatives of amino acid esters of ginkgolide B and their non-toxic pharmaceutically acceptable salts, as well as pharmaceutical compositions containing these compounds as active ingredients, and the compounds and pharmaceutical compositions as cardiovascular and cerebrovascular agents. Use of medicines for disease treatment. Background technique

[0002] Ginkgolide B is one of the strongest platelet activating factor antagonists discovered so far, it can be used clinically to treat thrombosis, acute pancreatitis and cardiovascular diseases, it also has protective effect on damaged neurons, and it has anti-oxidation, delays aging effect. However, the poor water solubility of ginkgolide B limits its clinical application.

[0003]

[0004] Ginkgolide B Contents of the invention

[0005] The present invention relates to derivatives of amino acid esters of ginkgolide B represented by structural formula I and ...

Claims

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