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Medicament for treating cervical ossified posterior longitudinal ligament

A technology of posterior longitudinal ligament and medicine, applied in the field of medicine and biology

Inactive Publication Date: 2010-11-17
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Type I collagen is the specific collagen in bone tissue, so whether high glucose is related to ligament ossification has not been reported in the literature

Method used

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  • Medicament for treating cervical ossified posterior longitudinal ligament
  • Medicament for treating cervical ossified posterior longitudinal ligament
  • Medicament for treating cervical ossified posterior longitudinal ligament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0045] cell culture

[0046] The animal experiment plan of this study was approved by the Animal Research Committee of Shanghai Jiaotong University. Three-month-old male Sprague-Dawley rats were killed by intravenous injection of pentobarbital sodium (150 mg / kg). The posterior longitudinal ligament of the cervical vertebra (C2-C7) was removed under aseptic conditions, and the connection part between the ligament and the bone was removed. The collected tissues were rinsed three times with PBS, cut into tissue pieces of about 1 mm2 with sterile scissors, spread them in a 35 mm Petri dish (Corning) with a small amount of DMEM, 10% FBS (Sigma), and 0.2 mM ascorbic acid, and placed in culture Cultivated in the box (5% CO 2 , 37°C). After waiting for the cells to climb out of the tissue block and grow to confluence, the cells were digested with 0.25% trypsin and 1 mM EDTA (Sigma) and passaged to 60 mm dishes. The 2nd to 5th passage cells were used for experiments. The passaged ...

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Abstract

The invention relates to the technical field of pharmaceutical biology, and provides application of medicaments for reducing hyperglycemia in the preparation of a medicament for treating cervical ossified posterior longitudinal ligament. The application confirms signal transduction pathways of promoting BMP-2 to induce ligament battery prophase osteogenic genes by high sugar, so the signal transduction pathways are connected with the medicinal treatment of patients who suffer from the cervical ossified posterior longitudinal ligament; and the medicament which acts on the signal transduction pathways can be invented to treat the patients who suffer from the cervical ossified posterior longitudinal ligament so as to provide the theoretical basis for research and development and screening of the medicament for treating the patients who suffer from the cervical ossified posterior longitudinal ligament.

Description

【Technical field】 [0001] The invention relates to the field of medical biotechnology, in particular to a medicine for treating cervical ossification of the posterior longitudinal ligament. 【Background technique】 [0002] Ossification of the posterior longitudinal ligament of the cervical spine (OPLL) refers to a disease in which the spinal cord and nerve roots are compressed due to ossification of the posterior longitudinal ligament of the cervical spine, resulting in sensory and motor disorders of the limbs and visceral autonomic dysfunction. Treatment of the disease includes conservative management and surgery. There is currently no effective drug for the treatment of cervical ossification of the posterior longitudinal ligament. [0003] Studies have confirmed that OPLL is a polygenic and multifactorial disease, but the specific mechanism of each factor is still unclear. Epidemiological surveys have shown that type 2 diabetes is an independent risk factor for the onset o...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P19/00
Inventor 李海戴力扬
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE