Synthesis method of m-phenoxytoluene

A m-phenoxytoluene, synthetic method technology, applied in the formation/introduction of ether group/acetal group/ketal group, ether preparation, organic chemistry, etc., can solve the problems of long steps and low total yield, etc. To achieve the effect of cost reduction

Inactive Publication Date: 2010-11-17
YANGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of reaction involves the introduction and removal of electron-withdrawing groups, which leads to long steps and low overall yields.

Method used

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  • Synthesis method of m-phenoxytoluene

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Embodiment Construction

[0012] Concrete reaction formula of the present invention is:

[0013]

[0014] In the formula, It means polydiethylene glycol, and any degree of polymerization can play a catalytic effect. The reaction condition is heating. The reaction equation shows: different substituted sodium phenates suitable for this method.

[0015] Specific steps are as follows:

[0016] 1. Put 126.5g of m-chlorotoluene, 23.2g of sodium phenoxide, 42g of cuprous chloride, 4.1g of 8-hydroxyquinoline, and 4.0g of polydiethylene glycol into a 500mL round bottom flask, and stir at room temperature for 5±1 minutes;

[0017] 2. Heat the mixture to 130-140°C while stirring;

[0018] 3. Insulate and stir the mixture at 130-140°C for 8-9 hours;

[0019] 4. After the reaction is over, high vacuum distillation (14-16 mmHg) is carried out, and the fraction at 100-110° C. can be obtained to obtain the final compound.

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Abstract

The invention discloses a synthesis method of m-phenoxytoluene, relating to a synthesis method of a compound. The synthesis method comprises the following steps of: stirring and mixing m-chlorotoluene, sodium phenate, cuprous chloride, 8-oxyquinoline and polydiglycol in a reaction container at the room temperature, heating until the temperature of mixed liquor is 130-140 DEG C and then reacting for 8-9 hours under thermal-insulation stirring; finally, carrying out high-vacuum reduced pressure distillation and getting 100-110 DEG C of distillates to obtain the m-phenoxytoluene. In the invention, under the catalytic action of the cuprous chloride, the 8-oxyquinoline and the polydiglycol, the sodium phenate and the m-chlorotoluene are directly taken as raw materials to carry out single-step reaction to prepare the m-phenoxytoluene, wherein the m-chlorotoluene is a reactant and meanwhile takes the solvent action so that any solvent does not need to be additionally used, thereby greatly reducing cost.

Description

technical field [0001] The invention relates to a synthetic method of a class of compounds, in particular to a synthetic method of m-phenoxytoluene and its analogues. Background technique [0002] m-phenoxytoluene is an important chemical intermediate, which is widely used in chemical materials, pharmaceutical chemicals and fine organic chemicals. [0003] The existing synthesis methods of m-methoxytoluene compounds are obtained by reacting sodium phenate and m-chlorotoluene substituted with electron-withdrawing groups under the catalysis of cuprous chloride and then further removing the electron-withdrawing groups. This type of reaction involves the introduction and removal steps of electron-withdrawing groups, which leads to the disadvantages of long steps and low overall yield. Simultaneously catalyzer cuprous chloride is heterogeneous catalyst in this reaction, and catalytic effect is unsatisfactory, when running into m-chlorotoluene that does not contain electron-withd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C43/275C07C41/01C07B41/04
Inventor 景崤壁林明朱贵吴林韬
Owner YANGZHOU UNIV
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