Application of Sulfaclozine and its derivatives
A technology of sulfachlorpyrazine and sulfachlorpyrazine sodium, which is applied in the field of medicine, can solve the problems of inability to completely kill parasites, large toxic and side effects, long medication time, etc., and achieves great application value and market prospects, drug safety, less toxic effect
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Embodiment 1
[0016] The preliminary screening test of embodiment 1 anti-toxoplasma gondii drug
[0017] In order to find effective anti-toxoplasma drugs, six drugs (azithromycin, tiamulin, clarithromycin, sulfachlorpyrazine sodium, metronidazole, and trimethoprim) that are commonly used in clinical practice were selected for anti-toxoplasma. Preliminary experiment of Toxoplasma gondii infection in mice.
[0018] (1) Preliminary experiment of comparison of 6 drugs
[0019] Set up 7 groups, 10 Kunming male mice in each group, 70 in total. Use the tachyzoites of Toxoplasma gondii (Toxoplasma gondii) Changning strain (CN strain, a virulent strain isolated from Shanghai diseased pigs), and press 1×10 4 Each mouse was intraperitoneally inoculated with mice, and the drug group was administered orally 4 hours after inoculation (see Table 1 for the drugs and doses used in each group), and the drug was used continuously for 6 days. On the 6th and 7th days after inoculation, each group was necropsi...
Embodiment 2
[0036] Embodiment 2 Different sulfonamide drug curative effect comparison experiment
[0037] Sulfonamides are a class of antibacterial drugs widely used in humans and animals. The mechanism of action of sulfa drugs is to interfere with the folic acid metabolism of Toxoplasma gondii, so that the growth and reproduction of Toxoplasma gondii are inhibited. Under normal conditions, Toxoplasma uses p-aminobenzoic acid to synthesize tetrahydrofolate with the participation of dihydrofolate synthase and reductase, and the basic structure of sulfonamides is similar to p-aminobenzoic acid, which can be combined with p-aminobenzoic acid Competing with each other for dihydrofolate synthase, hindering the formation of dihydrofolate so as to affect the synthesis of nucleic acid and protein, thereby inhibiting the growth and reproduction of Toxoplasma gondii. The compound of sulfadiazine and pyrimethamine is the control drug in the experiment of anti-toxoplasma gondii drug.
[0038] (1) E...
Embodiment 3
[0046] The drug safety test of embodiment 3 different sulfa drugs
[0047] Grouped healthy mice were directly fed with different drugs, and indicators such as health and body weight were observed. The mice were divided into 8 groups. The first 7 groups were fed with 7 different sulfa drugs for 5 days (see Table 5), and the 8th group was fed with the same amount of normal saline. During the experiment, each mouse was weighed every five days and the health status of the mice was recorded every day. The experiment lasted for 25 days.
[0048] The results showed that all the drugs were not lethal at the dose of 250mg / kg / day. The changes in body weight in Table 5 show that there is no significant difference between the weight gain of the trimethoprim lactate (TMP) irrigation group and the healthy control group. Sulfamethazine sodium (SDD), sulfamethoxypyridazine sodium (SMP) and sulfamethoxypyridazine sodium (SPZ) significantly increased the weight of mice compared with other dru...
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