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High-strength adhesive for treating fracture

A technology for the treatment of fractures and adhesives, applied in the field of high-strength adhesives, can solve problems such as poor injectability, inability to fill and repair places that need to be treated, and low mechanical strength, so as to accelerate biological mechanisms and promote rapid healing effect

Inactive Publication Date: 2010-11-24
北京悬壶京琼医药科技发展研究院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the traditional inorganic calcium phosphate bone cement has good biocompatibility and high bioactivity, its mechanical strength is too low, its compressive strength is low, its tensile strength is low, its brittleness is high, and its elastic modulus is greatly high. in natural bone
In addition, its injectability is poor, and it cannot accurately fill and repair the place that needs to be treated according to the defect site, and there are also problems such as difficulty in solidifying body fluids and blood.

Method used

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  • High-strength adhesive for treating fracture
  • High-strength adhesive for treating fracture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Dissolve 300mg of polyglycolic acid and 260mg of polylactic acid in 80ml of acetone to obtain solution A; dissolve 200mg of artificial protein A, 300mg of protein collagen, 100mg of biological enzyme, and 280mg of biologically active calcium in 450ml of pH7.2 phosphate buffer solution , to obtain solution B; at -4 ° C, quickly inject solution A into solution B under stirring at a speed of 800 rpm and continue to stir under magnetic conditions until the polylactic acid and polyglycolic acid ultrafine particles are solidified; the product obtained in the step After centrifugation at 10,000 revolutions / separation, washing with water and freeze-drying, ultrafine particles of high-strength adhesive are obtained. Add 20ml of distilled water to disperse evenly to obtain a high-strength adhesive.

Embodiment 2

[0012] Weigh 100mg of polyglycolic acid and 400mg of polylactic acid and dissolve in 90ml of acetone to obtain solution A; dissolve 300mg of artificial protein A, 200mg of protein collagen, 200mg of biological enzyme, and 100mg of bioactive calcium in 400ml of pH7.2 phosphate buffer solution , to obtain solution B; at -4 ° C, quickly inject solution A into solution B under stirring at a speed of 1000 rpm and continue to stir under magnetic conditions until the polylactic acid and polyglycolic acid ultrafine particles are solidified; the product obtained in the step After centrifugation at 10,000 revolutions / separation, washing with water and freeze-drying, ultrafine particles of high-strength adhesive are obtained. Add 10ml of distilled water to disperse evenly to obtain a high-strength adhesive.

Embodiment 3

[0014] Weigh 500mg of polyglycolic acid and 100mg of polylactic acid and dissolve in 85m] acetone to obtain solution A; dissolve 100mg of artificial protein A, 400mg of protein collagen, 50mg of biological enzyme, and 500mg of bioactive calcium in 600ml of pH7.2 phosphate buffer solution , to obtain solution B; at -4 ° C, quickly inject solution A into solution B under stirring at a speed of 1100 rpm and continue to stir under magnetic conditions until the polylactic acid and polyglycolic acid ultrafine particles are solidified; The product is centrifugally separated at 10,000 rpm, washed with water, and freeze-dried to obtain ultrafine particles of high-strength adhesive. Add 50ml of distilled water to disperse evenly to obtain a high-strength adhesive.

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Abstract

The invention discloses a high-strength adhesive for treating fracture. The adhesive comprises 100 to 300 milligrams of artificial protein A, 200 to 400 milligrams of protocollagen, 50 to 200 milligrams of biological zymogen, 100 to 500 milligrams of biological active calcium, 100 to 500 milligrams of polyglycolic acid, 100 to 400 milligrams of polylactic acid, and 10 to 50 ml of distilled water. A bone repair material of the invention has high biocompatibility and bone conduction property and can also be used for carrying out internal fixation of fracture and treatment for bone defect reconstruction in an injection mode.

Description

technical field [0001] The present invention relates to a high-strength adhesive for treating fractures. Background technique [0002] Bone cement is a kind of bone repair material that is easy to operate in clinical surgery, can be shaped arbitrarily and solidifies itself like cement, and has a wide range of applications in bone repair and other fields. One material currently available as a bone cement is polymethyl methacrylate (PMMA), which presents major problems with biocompatibility due to its composition being completely different from natural bone tissue. Although the traditional inorganic calcium phosphate bone cement has good biocompatibility and high bioactivity, its mechanical strength is too low, its compressive strength is low, its tensile strength is low, its brittleness is high, and its elastic modulus is greatly high. in natural bone. In addition, its injectability is poor, and it cannot accurately fill and repair the place to be treated according to the d...

Claims

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Application Information

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IPC IPC(8): A61L27/22
Inventor 曹建中赵一彭汝祥
Owner 北京悬壶京琼医药科技发展研究院
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