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Method for preparing hydroxypropyl cellulose

A technology of hydroxypropyl cellulose and refined cotton, which is applied in the field of preparation of hydroxypropyl cellulose, can solve the problems of difficult control of the reaction end point, long centrifugal washing time, difficult granulation of materials, etc., and shorten the granulation time and drying time , Reduce the effect of steam consumption and electricity consumption

Active Publication Date: 2012-05-09
ANHUI SUNHERE PHARMA EXCIPIENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Hydroxypropyl cellulose is often used as a pharmaceutical excipient. At present, 100 grades of refined cotton are often used as raw materials for the preparation of hydroxypropyl cellulose. The material reacts violently in the process of neutralization and hydrolysis, and it is difficult to control the reaction end point; the centrifugal washing time is long ; Materials are difficult to granulate; drying time is long

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The present invention is realized in this way, a method for preparing hydroxypropyl cellulose, the method steps are:

[0018] 1) Alkalization: Put the refined cotton with a degree of polymerization of 2200-2400 (product number refined cotton 650), 128kg of refined cotton into the kneader, turn on the stirring, put in 212kg of 30% liquid sodium hydroxide, 107kg of drinking water, and knead Keep the reaction at room temperature in the machine, the reaction time is 48 minutes, and the aging is 19 hours;

[0019] 2) Etherification: Put 128kg of aged alkalized cotton into the kneader, open the vacuum valve to draw a vacuum of -0.8M Pa, draw in 30kg of propylene oxide, start stirring, keep the reaction temperature at 70°C, and time the reaction time 72 minutes;

[0020] 3) Neutralization and hydrolysis: add 880kg of drinking water to the reactor, turn on the steam and raise the temperature to 60℃, start stirring and feeding, add 240kg of industrial hydrochloric acid with a mass fra...

Embodiment 2

[0028] The present invention is realized in this way, a method for preparing hydroxypropyl cellulose, the method steps are:

[0029] 1) Alkalization: Put refined cotton with a degree of polymerization of 2200-2400 (refined cotton 650), 192kg of refined cotton into the kneader, start stirring, put in 30% liquid sodium hydroxide 319kg, drinking water 160kg, and knead Keep the reaction at room temperature in the machine, the reaction time is 72 minutes, and the aging is 28 hours;

[0030] 2) Etherification: Put 192kg of aging alkalized cotton into the kneader, open the vacuum valve to draw a vacuum of -0.8M Pa, draw in 45kg of propylene oxide, start stirring, keep the reaction temperature at 80°C, and time the reaction time 108 minutes;

[0031] 3) Neutralization and hydrolysis: Add 1320kg of drinking water into the reactor, turn on the steam and raise the temperature to 90°C, start stirring and feed, add 360kg of industrial hydrochloric acid with a mass fraction of 30% for neutralizat...

Embodiment 3

[0039] The present invention is realized in this way, a method for preparing hydroxypropyl cellulose, the method steps are:

[0040] 1) Alkalization: Put refined cotton with a degree of polymerization of 2200-2400 (product number 650 refined cotton), 150kg of refined cotton into the kneader, start stirring, put in 30% liquid sodium hydroxide 260kg, drinking water 140kg, and knead Keep the reaction at room temperature in the machine, the reaction time is 60 minutes, and the aging is 20 hours;

[0041] 2) Etherification: Put 160kg of aged alkalized cotton into the kneader, open the vacuum valve to draw a vacuum of -0.8M Pa, draw in 40kg of propylene oxide, turn on the stirring, keep the reaction temperature at 70°C, and time the reaction time 80 minutes;

[0042] 3) Neutralization and hydrolysis: add 1000kg of drinking water into the reactor, turn on the steam and raise the temperature to 70℃, start stirring and feeding, add 300kg of industrial hydrochloric acid with a mass fraction o...

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Abstract

The invention discloses a method for preparing hydroxypropyl cellulose. The method comprises the following steps of: 1) basification; 2) etherification; 3) neutralizing hydrolysis; 4) centrifugal washing; 5) granulation; 6) drying; 7) crushing; 8) screening; and 9) packaging. The method has the advantages of: shortening the washing time and saving the water consumption during centrifuging, shortening the granulation time and reducing the electric energy consumption during the granulation, shortening the drying time and reducing the steam consumption and the electric energy consumption during the drying and doubling the yield under the condition of the same working hours and energy consumption, along with energy conservation and environmental protection.

Description

Technical field [0001] The invention relates to a method for preparing hydroxypropyl cellulose. Background technique [0002] Hydroxypropyl cellulose is often used as a pharmaceutical excipient. At present, 100 grade refined cotton is commonly used as a raw material in the preparation of hydroxypropyl cellulose. The material in this process reacts violently during the neutralization and hydrolysis process, and it is difficult to control the reaction end point; the centrifugal washing time is long ; The material is difficult to granulate; the drying time is long. Summary of the invention [0003] The purpose of the present invention is to provide a method for preparing hydroxypropyl cellulose, which improves the production capacity and reduces the energy consumption. [0004] The present invention is realized in this way. A method for preparing hydroxypropyl cellulose is characterized in that the method steps are: [0005] 1) Alkalization: Put 128-192kg of refined cotton of 650 grade...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B11/08
Inventor 张学全朱岩周卫东陈晓雪
Owner ANHUI SUNHERE PHARMA EXCIPIENTS