Centrifugal double-channel trace liquid quantitative sampling device and manufacturing method thereof

A technology of trace liquid and sample introduction device, which is applied in sampling device, preparation of test samples, photoengraving process of pattern surface, etc. The effect of simple process, low cost and easy integration

Inactive Publication Date: 2010-11-24
CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims to solve the problem that the micro-liquid quantitative sampling structure in the existing centrifugal microfluidic chip is a single liquid quantitative structure, and the manufacturing process is complicated, the integration precision is low, secondary centrifugation is required during use, and the operation process is cumbersome. Centrifugal dual-channel trace liquid quantitative sampling device and manufacturing method thereof

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  • Centrifugal double-channel trace liquid quantitative sampling device and manufacturing method thereof
  • Centrifugal double-channel trace liquid quantitative sampling device and manufacturing method thereof
  • Centrifugal double-channel trace liquid quantitative sampling device and manufacturing method thereof

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specific Embodiment approach 1

[0028] Specific implementation mode 1. Combination Figure 1 to Figure 4 Description of this embodiment, a centrifugal double-channel trace liquid quantitative sampling device is composed of a PDMS substrate 1 and a glass sheet 2, and the PDMS substrate 1 is placed on the surface of the glass sheet 2; the PDMS substrate The surface of 1 is provided with a first trace liquid quantitative sampling unit and a second trace liquid quantitative sampling unit;

[0029] The first trace liquid quantitative sampling unit includes a first waste liquid chamber 3, a first waste liquid chamber exhaust channel 4, a first liquid sampling hole 6, a first inverted V-shaped liquid quantitative chamber 7, a first liquid injection Cut off the air inlet channel 8 and the liquid outlet channel 10; the exhaust channel 4 of the first waste liquid chamber is arranged on the first waste liquid chamber 3; one end of the first inverted V-shaped liquid quantitative chamber 7 is connected to the first liqui...

specific Embodiment approach 2

[0037] Embodiment 2. This embodiment is a manufacturing method of a centrifugal dual-channel trace liquid quantitative sampling device described in Embodiment 1. The method is completed by the following steps:

[0038] Step 1. On SiO 2 The surface of the single wafer is spin-coated with photoresist, and the first waste liquid chamber 3, the first waste liquid chamber exhaust channel 4, and the first inverted V-shaped liquid quantitative sampling unit are photoetched out. Chamber 7, the first liquid interrupts the intake passage 8, the liquid outlet passage 10, the second waste liquid chamber 13 in the second trace liquid quantitative sampling unit, the second waste liquid chamber exhaust passage 14, the second inverted V-shaped The liquid quantitative cavity 17, the second liquid interrupt the SiO of the intake channel 18 and the gas blocking valve exhaust channel 20 2 mask pattern;

[0039] Step 2, the SiO obtained in step 1 2 Evaporate a 1 μm thick aluminum film on the ma...

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Abstract

The invention discloses a centrifugal double-channel trace liquid quantitative sampling device and a manufacturing method thereof, and relates to a sampling structure for centrifugal double-channel trace liquid quantitative sampling. The device solves the problems that the trace liquid quantitative sampling structure in the conventional centrifugal micro-fluidic chip is a single liquid quantitative structure, has complex manufacturing process and low integration precision, needs secondary centrifugation during use and has fussy operation processes. The device consists of a PDMS substrate and a glass sheet, wherein the PDMS substrate is stuck on the surface of the glass sheet; the surface of the PDMS substrate is provided with two trace liquid quantitative sampling units; each liquid quantitative sampling unit comprises an inverse V-shaped liquid quantitative cavity, a liquid breaking air inlet channel, a waste liquid cavity, a liquid outlet channel and the like; one end of each inverse V-shaped liquid quantitative cavity is communicated with the waste liquid cavity; and the other end of the inverse V-shaped liquid quantitative cavity is communicated with the liquid outlet channel. The device is applicable in the quantitative sampling field for bio-chemically detecting trace liquid in the centrifugal micro-fluidic chip.

Description

technical field [0001] The invention relates to a sampling structure for centrifugal double-channel trace liquid quantitative sampling. Background technique [0002] The microfluidic chip for biochemical detection is a multifunctional system chip, often called Lab-on-a-chip (Lab-on-a-chip), which integrates sample preparation, quantitative injection, liquid mixing, biochemical reaction, The basic operation units such as separation and detection are integrated or basically integrated on a chip of a few square centimeters, which is a technical platform used to replace various functions of conventional chemical or biological laboratories. The basic feature and biggest advantage of microfluidic chips are the flexible combination and large-scale integration of various unit technologies on an overall controllable micro platform. Among them, the precise quantification and sampling of microliter-level liquids are the most basic and important operation steps before the mixing and bi...

Claims

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Application Information

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IPC IPC(8): G01N1/10G01N1/38G03F7/00
Inventor 张平邓永波吴一辉刘震宇刘永顺武俊峰
Owner CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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