High-sensitivity integrated optical waveguide sensor based on digital droplet sample introduction channel

Abstract

The invention discloses a high-sensitivity integrated optical waveguide sensor based on a digital droplet sample introduction channel, which comprises a digital droplet sample introduction channel, an input optical waveguide, an output optical waveguide, an integrated planar optical waveguide sensor, a photodetector and a phase-locking amplifier, wherein the integrated planar optical waveguide sensor is coupled with the input and output optical waveguides; the photodetector converts photosignals in the output optical waveguide into electric signals; the phase-locking amplifier is connected with the photodetector; and the integrated planar optical waveguide sensor, which is coupled with the input and output optical waveguides, is arranged in the digital droplet sample introduction channel and below the position after the buffer solution and the substance to be measured are mixed to form droplets. The invention enables the substance to be measured to flow across the sensing region of the integrated optical waveguide sensor in the frequency f, and modulates the optical waveguide output signal output by the sensor in the frequency f, so that the output signal is converted into an alternating current signal; and the effective signals with the frequency f are extracted by the phase-locking amplifier to maximally filter out noise, mainly including white noise which is introduced by the laser device and the photodetector, thereby enhancing the sensitivity of the sensor.

Description

technical field [0001] The invention relates to an integrated optical waveguide sensor, in particular to a high-sensitivity integrated optical waveguide sensor device based on a digital droplet sampling channel. Background technique [0002] Optical biochemical sensors have the characteristics of no electromagnetic interference and high sensitivity. They are not only widely used in the field of traditional medicine to promote the development of medicine, but also have a wide range of applications in the fields of space life science, food industry, environmental monitoring and fermentation engineering. [0003] There are two main approaches for biochemical sensing using optical methods: one is based on fluorescence detection, and the other is label-free. For fluorescence detection, specific fluorescent markers are required to label the substance to be tested, and the required biochemical information can be obtained by detecting the intensity of fluorescence. Although it has h...

AI Technical Summary

Problems solved by technology

The current microfluidic sampling system is basically a continuous microfluidic sampling system, and the output optical signal is a DC signal. This system can play the role of sampling the detected substance, but it does not help to improve the detection accuracy.

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