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Multilayered body for medical containers and medical container

A medical container and multi-layer technology, which is applied in the direction of medical containers, medical packaging, household containers, etc., can solve the problem of reducing the concentration of medicines, and achieve the effects of good adhesion resistance, good bonding, and excellent heat resistance

Active Publication Date: 2010-12-01
HOSOKAWA YOKO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Among these resins, polyethylene is widely used in medical containers because it is highly hygienic and soft, and does not generate toxic gas during incineration. If ethylene is used, the polyethylene in the liquid medicine will absorb specific drugs such as fat-soluble vitamins, and the concentration of specific drugs may decrease during storage.

Method used

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  • Multilayered body for medical containers and medical container
  • Multilayered body for medical containers and medical container
  • Multilayered body for medical containers and medical container

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] The medical container 20 of Fig. 2 filled with 100 ml of water was manufactured in the following manner.

[0095] First, the housing part 21 and the mouth part 22 are integrally molded by the multi-layer blow molding method using a multi-layer blow molding machine. , and a blow molded body with a three-layer structure of the outermost layer with a thickness of 20 μm is formed. Next, 100 ml of water is filled into the accommodating portion 21 from the mouth portion 22 , and then the rubber stopper body 22 a and the mouth portion 22 are heat-sealed to seal the medical container 20 . As the rubber plug body 22a, the melt flow rate (hereinafter referred to as "MFR" at 280° C. based on ISO 1133, which is set by injection molding on the outer peripheral part. In addition, in Examples and Comparative Examples, when MFR is measured, All of the loads are 21.18N.) The rubber of the layer formed by the cyclic polyolefin "Zonex (manufactured by Nippon Zenon Co., Ltd.)" (hereinafte...

Embodiment 2

[0121] Except for changing the composition of the outermost layer and the composition of the mouth portion 22 in Example 1, the medical container 20 was obtained in the same manner.

[0122] The MFR at 190°C for the outermost layer is 1.1g / 10 minutes, and the density is 0.927g / cm 3 High-pressure low-density polyethylene "Novatec (manufactured by Japan Polyechlen Co., Ltd.)" has an MFR of 3.5 g / 10 minutes at 190°C and a density of 0.956 g / cm 3 High-density polyethylene "Novatec (manufactured by Nippon Polyechelen Co., Ltd.)" was mixed at a mass ratio of 7:3.

[0123] The mouth 22 is constructed by heating a cylindrical member made of cyclic polyolefin manufactured by injection molding in a preheated mold set at 250° C. The inner 22 side of the mouth of the housing part 21 formed by the body, and heat-sealed installation at 220 ° C. In addition, after filling 100 mL of water, a rubber stopper was filled in the cylinder member, and an annular cover member was further arranged s...

Embodiment 3

[0125] A medical container 20 was obtained in the same manner as in Example 1 except that only COP2 was used for forming the innermost layer, and the same evaluation was performed. The results are shown in the table.

[0126] In addition, in this embodiment, as the rubber plug body 22a, a layer formed of LLDPE used as an intermediate layer is provided on the outer peripheral portion of the rubber plug by injection molding.

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Abstract

It is intended to provide a multilayered body for medical containers in which the innermost layer made of a cyclic polyolefin is well adhered to another layer without resorting to an adhesive and which is excellent in heat resistance and, in the case of being in a film shape, also excellent in blocking resistance, and a medical container which is made of the above multilayered body for medical containers and shows little deterioration in characteristics such as transparency and peeling strength even after sterilized with high pressure steam or the like.

Description

technical field [0001] The present invention relates to a multilayer body for medical containers, and a medical container having a medical solution storage portion formed of the multilayer body for medical containers. Background technique [0002] Examples of resin medical containers used in the medical field include ampoules, vials, injection containers, film infusion bags, and the like. In addition, as the resin, polyolefins such as polyethylene and polypropylene, styrene-based elastomers, vinyl chloride resins, ethylene-vinyl acetate copolymers, cyclic polyolefins, and the like can be used. [0003] Among these resins, polyethylene is widely used in medical containers because it is highly hygienic and soft, and does not generate toxic gas during incineration. If ethylene is used, specific chemicals such as fat-soluble vitamins will be adsorbed to polyethylene in the drug solution, and the concentration of the specific drugs may decrease during storage. [0004] Therefor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/10B32B27/30
CPCA61J1/10B32B2307/306B32B27/325B32B27/08A61J1/2093B32B2307/412B32B2307/308B32B2307/72B32B2439/80B32B27/32B32B27/327B32B2307/744
Inventor 中村学宫城浩
Owner HOSOKAWA YOKO CO LTD
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