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Chinese medicinal composition for treating malignant tumor diseases and preparation method thereof

A technology of composition and traditional Chinese medicine, which is applied in the direction of drug combination, antineoplastic drugs, and pharmaceutical formulas, can solve the problems of large investment, long cycle, and high risk of new drug research and development, and achieve fast absorption, convenient administration, and strengthening the immune function of the body. Effect

Active Publication Date: 2010-12-08
常熟雷允上制药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high risk, large investment and long cycle of research and development of new drugs, few anti-tumor Chinese patent medicines have been released in recent years. Currently, Western medicines account for 75% of the cancer drug market, while Chinese patent medicines only account for 25%.

Method used

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  • Chinese medicinal composition for treating malignant tumor diseases and preparation method thereof
  • Chinese medicinal composition for treating malignant tumor diseases and preparation method thereof
  • Chinese medicinal composition for treating malignant tumor diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. The composition of raw materials of the traditional Chinese medicine composition: 30 kg of astragalus extract, 30 kg of asparagus extract, 15 kg of bergamot extract, and 25 kg of American ginseng extract.

[0028] 2, the preparation method of Chinese medicine composition preparation:

[0029] (1) Take Astragalus membranaceus coarse powder, add 20 times the amount of water for ultrasonic extraction for 80 minutes, the water extract is filtered through an ultrafiltration membrane, and the ultrafiltrate cuts off 50,000 to 6,000 molecular weight, concentrate, add 95% ethanol until the alcohol concentration reaches 80%, Precipitated polysaccharides, dried in vacuum to obtain the crude product of Astragalus polysaccharides; the astragalus dregs after ultrasonic extraction with water were extracted with 20 times 80% ethanol for 80 minutes, the ethanol was recovered from the extract, and combined with the water extract with a molecular weight below 6000 after ultrafiltration,...

Embodiment 2

[0035]1. The composition of raw materials of the traditional Chinese medicine composition: 40 kg of astragalus extract, 40 kg of asparagus extract, 25 kg of bergamot extract, and 35 kg of American ginseng extract.

[0036] 2, the preparation method of Chinese medicine composition preparation:

[0037] (1) Take the coarse powder of Astragalus membranaceus, add 15 times the amount of water and ultrasonically extract for 60 minutes, the water extract is filtered through an ultrafiltration membrane, the ultrafiltrate cuts off the molecular weight part of 50000~6000, concentrate, add 95% ethanol until the alcohol concentration reaches 80%, Precipitate polysaccharides, dry in vacuum to obtain crude product of Astragalus polysaccharides; take water and ultrasonically extract Astragalus medicinal residues, then use 18 times 80% ethanol to ultrasonically extract for 60 minutes, recover ethanol from the extract, and combine it with the water extract with a molecular weight below 6000 aft...

Embodiment 3

[0043] 1. The composition of raw materials of the traditional Chinese medicine composition: 20 kg of astragalus extract, 20 kg of asparagus extract, 10 kg of bergamot extract, and 15 kg of American ginseng extract.

[0044] 2, the preparation method of Chinese medicine composition preparation:

[0045] (1) Take the coarse powder of Astragalus membranaceus, add 18 times the amount of water and ultrasonically extract it for 80 minutes, the water extract is filtered through an ultrafiltration membrane, the ultrafiltrate cuts off the molecular weight part of 50000~6000, concentrate, add 95% ethanol until the alcohol concentration reaches 80%, Precipitated polysaccharides, dried in vacuum to obtain the crude product of Astragalus polysaccharides; the astragalus dregs after ultrasonic extraction with water were extracted with 18 times 80% ethanol for 80 minutes, the ethanol was recovered from the extract, and combined with the water extract with a molecular weight below 6000 after ul...

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Abstract

The invention discloses a Chinese medicinal composition and a preparation method and application thereof. The Chinese medicinal composition is prepared from 20 to 40 percent of astragalus extract, 20 to 40 percent of asparagus root extract, 5 to 25 percent of finger citron extract and 15 to 35 percent of American ginseng in percentage by weight. Pharmacological experiments and clinical experiments show that the Chinese medicinal composition provided by the invention has the functions of strengthening body resistance and eliminating evil, nourishing yin and tonifying qi, clearing heat and releasing toxin, eliminating tuberculosis and dissipating stagnation, and mainly treats the symptoms of qi and yin deficiency, qi stagnation, blood stasis, phlegm coagulation, toxin aggregation and the like caused by malignant tumors; when the Chinese medicinal composition is used with radiation therapy and chemical therapy, the Chinese medicinal composition has the effects of increasing efficacy, reducing toxicity and inhibiting growth and transfer of the tumors, can reverse the medicament resistance of tumor cells and promote apoptosis of the tumor cells, and has not obvious toxic or side effect; and meanwhile, the preparation method for the Chinese medicinal composition has the advantages of quality stability and controllability, extraction of high active ingredient content and strong operability, and is suitable for industrialized mass production.

Description

technical field [0001] The invention relates to a medicine, in particular to a traditional Chinese medicine composition, a preparation method thereof and an application of the traditional Chinese medicine composition in treating malignant tumor diseases. Background technique [0002] Tumor has become the number one killer threatening human survival in the 21st century, with an average of 6.7 million people dying from various tumor diseases every year. China is one of the countries with a high incidence of cancer in the world. There are 2.2 million new cancer patients every year, accounting for 20% of the global total. There are currently 4.5 million cancer patients, and there is a rapid growth trend every year. Clinically, the current drugs for treating tumors mainly include chemical drugs. However, due to the high toxicity of chemotherapy drugs, they can not selectively kill white blood cells, lymphocytes and other human immune cells while killing tumor cells. As a result, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8965A61P35/00
Inventor 顾治平荆海英王恒斌陈力建
Owner 常熟雷允上制药有限公司
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