Method for preparing borneol by using natural camphor powder as raw material

A refining method and natural technology, applied in the preparation of metal alcohols, chemical instruments and methods, preparation of hydroxyl compounds, etc., can solve the problems of failure to realize industrial production, low conversion rate and yield, and many reaction by-products, etc. The effect of low cost, few by-products and short reaction time

Inactive Publication Date: 2010-12-08
HUAQIAO UNIVERSITY
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Problems solved by technology

[0005] Traditionally, the method of synthesizing borneol is to use turpentine or α-pinene (α-pinene is also one of the main components of turpentine) as raw materials, and obtain through steps such as fractionation, esterification, distillation, saponification, separation and purification, and its main disadvantages Yes: more reaction steps, longer technical route, more reaction by-products, and the obtained product is a mixture of D-borneol and L-borneol which is nearly half in half
Overall, the conversions and yields of these methods are low
[0010] The above research results have not been able to realize industrial production

Method used

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  • Method for preparing borneol by using natural camphor powder as raw material
  • Method for preparing borneol by using natural camphor powder as raw material

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Embodiment 1

[0033] The invention discloses a method for preparing borneol by using natural brain powder as a raw material. The borneol is a mixture of D-borneol and L-borneol mainly composed of D-borneol. In the alkali metal / absolute ethanol reduction system, the D-camphor in the natural brain powder is mainly converted into D-borneol by utilizing the two intermediate products generated by D-camphor in the reduction process with different thermodynamic stability characteristics. ; It comprises the following preparation steps: refining of natural brain powder → asymmetric reduction reaction → vacuum distillation and separation of primary reduction products → secondary reduction of camphor in primary reduction products → vacuum distillation and separation of secondary reduction products → Obtain the target product. The natural brain powder is a by-product obtained after extracting various spice products from natural camphor tree oil.

[0034] 1. Refining of natural brain powder

[0035] T...

Embodiment 2

[0072] Refining of natural brain powder:

[0073] Weigh 10g of natural brain powder, put it into a 200mL beaker, add 100mL of deionized water, fully stir it with a glass rod, let it stand for 10min, filter it with a Buchner funnel, put the filter cake in a vacuum drying oven and dry it for 24 hours.

[0074] Weigh about 3g of camphor and add it to a 100mL three-necked round-bottomed flask, add about 25g (32mL) of required dehydrated alcohol, make camphor fully dissolved in dehydrated alcohol, filter with a Buchner funnel, filter to remove neither water-soluble, Also insoluble solid impurities in absolute ethanol, the filtrate is used for later use.

[0075] Other methods and steps are carried out with reference to Example 1.

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Abstract

The invention discloses a method for preparing borneol by using natural camphor powder as a raw material. In an alkali metal/anhydrous ethanol reduction system, d-camphor in the natural camphor powder is mainly transformed into d-borneol by using the characteristics of different thermodynamic stabilities of two intermediate products generated by reduction of the d-camphor. The method has the following preparation steps of: refining of the natural camphor powder, asymmetric reduction reaction, reduced pressure distillation and separation of a primary reduced product, secondary reduction of camphor in the primary reduced product, reduced pressure distillation and separation of a secondary reduced product, and obtaining of a target product. The reaction raw materials are natural products of green resources, and relate to comprehensive utilization of spice plants; the conversion rate of the reactants is high and close to 100 percent; because of one-step reaction, the byproducts are few, and the product has high purity; and the method has the advantages of short synthesizing process, low equipment investment, low production cost, high economic benefit, mild reaction condition, short reaction time, low environmental pollution and nearly no environmental pollution.

Description

technical field [0001] The invention relates to a preparation method for synthesizing borneol by using natural brain powder as a raw material through one-step asymmetric reduction reaction. The product is a mixture of dextroborneol and levoborneol with dextroborneol as the main component, belonging to the technical field of biomedicine and spice production . Background technique [0002] Borneol is a colorless, transparent or white flaky crystal, named for its crystal clear appearance. Borneol, also known as borneol, has two structures, left-handed and right-handed, and can be divided into natural borneol and synthetic borneol. Natural dextroborneol (commercial name Meipian) is a natural substance extracted from dipterocarp. Since dipterocarp has no resource distribution in my country, my country has obtained natural borneol from Borneo and Sumatra in history. The name "brain" shows its preciousness. Natural left-handed borneol (trade name Ai Pian) is processed and chopped...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C35/30C07C29/143C07C31/30C07C29/70C07C29/80C07C29/86
Inventor 王维德赵鹏王宁辉黄颖芬
Owner HUAQIAO UNIVERSITY
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