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Forsythoside A drug composite

A technology of forsythiaside and composition, applied in the field of pharmaceutical compositions, can solve problems such as low oral bioavailability, and achieve the effects of high oral bioavailability, good absorption and high blood drug concentration

Inactive Publication Date: 2010-12-22
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the defect of low oral bioavailability of the existing forsythiaside A drug, and to provide a drug that is better absorbed in the gastrointestinal tract, can obtain higher blood drug concentration, and has oral bioavailability. High forsythiaside A pharmaceutical composition

Method used

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  • Forsythoside A drug composite
  • Forsythoside A drug composite
  • Forsythoside A drug composite

Examples

Experimental program
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Effect test

Embodiment 1～33

[0021] The medicinal forsythoside A composition of the present invention can be used to dissolve or uniformly disperse forsythoside A by ultrasonic or vibration according to the components and content ratios described in Table 1.

[0022] Table 1. The components and contents of the pharmaceutical compositions of Examples 1 to 32

[0023]

[0024]

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Abstract

The invention discloses a forsythoside A drug composite, which contains forsythoside A and oleaginous base plant extract, wherein, the mass ratio of forsythoside A to oleaginous base and / or oleaginous base plant extract is 0.05:10-0.5:10. The forsythoside A drug composite can be well absorbed in gastrointestinal tracts, can acquire higher blood concentration, and has high oral bioavailability.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical compositions, and particularly relates to a forsythiaside A pharmaceutical composition. Background technique [0002] Forsythia is a deciduous shrub (Forsythia Suspensa (Thunb.Vahl)) plant in Oleaceae. Forsythia fruit is generally used in traditional Chinese medicine. Forsythia is mainly distributed in Shanxi, Henan, Shaanxi, Shandong and other places in my country. Modern pharmacology shows that Forsythia has antibacterial, antiviral, hepatoprotective, anti-inflammatory and antipyretic effects. Forsythia contains a variety of chemical components, mainly including phenethyl alcohol caffeic acid glycosides, lignans, flavonoids, terpenes and C 6 -C 2 Natural alcohols, among which phenethyl alcohol caffeoside (ie forsythiaside) is the main active ingredient of medicine, and among them, forsythiaside A, which has the highest content, acts. Forsythiaside A has strong anti-oxidant, anti-bacterial, anti-viral,...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61K47/44A61K47/12A61K47/14A61K47/34A61P39/06A61P31/00A61P31/12A61P1/16A61P13/12
Inventor 陆伟根王莉莉陈亭亭虞丽芳杨耀杰
Owner SHANGHAI INST OF PHARMA IND
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