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Application of coryebactrium parvum in preparing medicament for treating novel A H1N1 influenza viruses

A technology for influenza virus infection and short rod-shaped bacillus, applied in the field of medicine, can solve the problem of indetermination of the toxicity of the new type A H1N1 influenza virus, the origin of the transmissible virus, the inability to judge the degree of spread, the unclear incubation period and infectious period of the virus, etc. problem, to achieve the effect of reducing fever, improving absorption and diffusion, and uniform particle size

Inactive Publication Date: 2010-12-22
上海铭源数康生物芯片有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the virulence, transmissibility and origin of the new type A H1N1 influenza virus are still uncertain, and the incubation period and infectious period of the virus are not very clear, scientists are still unable to judge the extent of its spread around the world

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0060] Experimental Example 1 The protective effect of NCP on mouse new type A H1N1 influenza virus infection:

[0061] 1. Materials and Methods

[0062] 1.1. Test product: NCP (2mg / ml), stored at 4°C, prepared with normal saline when used. 0.25mg / piece, 0.5mg / piece, 1mg / piece

[0063] 1.2. Virus: new type A H1N1 influenza virus, from WHO, passaged in the allantoic cavity of chicken embryos, the experimental virus is E22-23 generations, and the hemagglutination titer is above 1 / 180 (chicken embryos are 10-11 days old) .

[0064] 1.3. Mice: Kunming mice, weighing 10-12 grams,

[0065] 1.4. Mice influenza virus toxin protection test: After intramuscular injection of NCP, mice were intravenously injected with new type A H1N1 influenza virus at different times. A virus control group was set up to observe death and calculate the protection rate.

[0066] 2. Experimental process

[0067] 2.1 Animal model: Intravenous injection of 1×10 new type A H1N1 influenza virus into mice ...

Embodiment 2

[0082] 1. Materials and Methods

[0083] 1.1. Test product: CPP,

[0084] 1.2. Virus: new type A H1N1 influenza virus, from WHO, passaged in the allantoic cavity of chicken embryos, the experimental virus is E22-23 generations, and the hemagglutination titer is above 1 / 180 (chicken embryos are 10-11 days old) .

[0085] 1.3. Mice: Kunming mice, weighing 10-12 grams,

[0086] 1.4. Mice influenza virus toxin protection test: after intramuscular injection of CPP, mice were intravenously injected with new type A H1N1 influenza virus at different times, a virus control group was set up, death was observed, and the protection rate was calculated.

[0087] 2. Experimental process

[0088] 2.1 Animal model: Intravenous injection of 1×10 new type A H1N1 influenza virus into mice 5 Virus / 0.2ml / only

[0089] 2.2 Dosage, Grouping and Administration

[0090] 1) Normal control group: 20 rats, injected intramuscularly with 0.2ml of normal saline per rat

[0091] 2) Virus control group...

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Abstract

The invention relates to application of a coryebactrium parvum preparation (CPP) or a noncellular coryebactrium parvum preparation (NCP) in the field of pharmacy, in particular to application in preparing a medicament for treating novel A H1N1 influenza viruses. The coryebactrium parvum preparation is a preparation prepared by inactivating coryebactrium parvum through formaldehyde; and the noncellular coryebactrium parvum preparation is of a nanometer grade and has uniform grain size, enhanced absorbance and diffusance and low heat source without formaldehyde residuals. The CPP plays a certain role of resisting the novel A H1N1 influenza viruses, and especially, the effect of the NCP is more obvious.

Description

technical field [0001] The invention relates to the application of a short coryneform bacterium preparation (CPP) or a cell-free breve coryneform bacterium preparation (NCP) in the field of pharmacy, in particular to the application in preparing a medicament for treating novel type A (H1N1) influenza virus, and belongs to the field of medicine. Background technique [0002] Influenza is a contagious disease caused by the influenza virus that spreads through the respiratory tract. Influenza pandemics in history have caused serious consequences to humans. For example, the "Spanish flu" caused by the H1N1 subtype influenza virus that broke out in 1918 was the most disastrous influenza in the 20th century. It infected half of the world's population and killed tens of millions of people. Influenza pandemics are usually caused by a new virus or a virus that has never been infected before. The human body has no immunity to this new virus. In addition, its spread is wide and fast, ...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P31/16
Inventor 高尚先
Owner 上海铭源数康生物芯片有限公司
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