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Potassium glycyrrhizinate preparation method

A technology of potassium glycyrrhizinate and ammonium glycyrrhizinate, applied in the field of medicine and chemical industry, to achieve the effects of no reaction by-products, easy promotion, and strong practicability

Active Publication Date: 2013-04-10
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technology provided by the invention is novel, easy to operate, energy-saving and environmentally friendly, and has good practicability. At present, there is no relevant patent or literature report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 5 kg of glycyrrhizic acid monoammonium salt with a content of 75%, add 35 L of water to dissolve at 45°C, and obtain a glycyrrhizic acid monoammonium salt solution.

[0028] Take the glycyrrhizic acid monoammonium salt solution and pass it through a macroporous adsorption resin column of type HP-20. After the column is completed, add water to fully elute to remove other impurities, and then use 31 L of potassium carbonate solution with a concentration of 1.0% to elute and collect. The eluate was concentrated under reduced pressure to 10L to obtain a concentrated solution of monopotassium glycyrrhizic acid.

[0029] Take the concentrated solution, add it into 20L of ethanol solution, stir, stand for crystallization, filter and dry to obtain 4.2kg of glycyrrhizic acid monopotassium salt.

Embodiment 2

[0031] Take 10 kg of diammonium glycyrrhizinate with a content of 98%, add 70 L of water to dissolve at 50° C. to obtain diammonium glycyrrhizinate solution.

[0032] Take the diammonium glycyrrhizinate solution and pass it through an ion exchange resin column of type D301. After the column is completed, add water to fully elute to remove other impurities, and then use 130 L of potassium hydroxide solution with a concentration of 0.5% to elute, and collect the elution. The solution was concentrated under reduced pressure to 18L to obtain dipotassium glycyrrhizinate concentrate.

[0033] Take the concentrated solution, add it into 36L of ethanol solution, stir, stand for crystallization, filter and dry to obtain 9.7kg of dipotassium glycyrrhizinate.

Embodiment 3

[0035] Take 5 kg of glycyrrhizic acid monoammonium salt with a content of 90%, add 30 L of water and dissolve at 40°C to obtain a glycyrrhizic acid monoammonium salt solution.

[0036] Take glycyrrhizic acid monoammonium salt solution and pass it through a macroporous adsorption resin column of type HPD-100. After the column is completed, add water to fully elute to remove other impurities, and then use 60L of potassium hydroxide solution with a concentration of 1.0% to elute. The eluate was collected and concentrated to 7.5L under reduced pressure to obtain dipotassium glycyrrhizinate concentrated solution.

[0037] Take the concentrated solution, add it into 15L ethanol solution, stir, stand for crystallization, filter and dry to obtain 4.6kg of dipotassium glycyrrhizinate.

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PUM

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Abstract

The invention provides a potassium glycyrrhizinate preparation method, mainly comprising the processes of dissolution, column chromatography, ion exchange and crystallization. The preparation process of the invention has good repeatability, the obtained potassium glycyrrhizinate has low cost and reliable and controllable quality, and the preparation method is suitable for industrialized production.

Description

technical field [0001] The invention discloses a method for preparing potassium glycyrrhizate, which belongs to the field of medicine and chemical industry. Background technique [0002] Licorice is the root and rhizome of legumes Glycyrrhiza uralensis Fisch., Glycyrrhiza in flata Bat., or Glycyrrhiza glabra L., mainly produced in Inner Mongolia, Xinjiang, Gansu and other places. Licorice has a long history of being used as medicine. "Shen Nong's Materia Medica" listed it as the superior medicine. Due to its precious resources, it has been listed as a national second-class protected wild medicinal material by the state. [0003] The main component of licorice is glycyrrhizin, also known as glycyrrhizic acid, also known as glycyrrhizin due to its sweet taste. With the in-depth study of glycyrrhizic acid's antiviral, anti-inflammatory, and hepatoprotective effects, various preparations based on glycyrrhizic acid and glycyrrhizic acid salts have been widely used in clinical p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00C07H15/256C07H1/00
Inventor 杨永安
Owner JIANGSU TIANSHENG PHARMA
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