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A kind of preparation method of beta glycyrrhizic acid monoammonium salt

A technology of glycyrrhizic acid monoammonium salt and glycyrrhizic acid is applied in the field of medicine and chemical industry to achieve the effects of low production cost, high product yield and few impurities

Active Publication Date: 2015-11-18
HUAIAN BROTHER BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technology provided by the invention is novel, easy to operate, energy-saving and environmentally friendly, and has good practicability. At present, there is no relevant patent or literature report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Get content and be 28.8% beta glycyrrhizic acid raw material 20kg, pulverize, cross 100 mesh sieves, be placed in reactor; Pass into ammonia gas in reactor, stir reaction 3.5 hours, stop reaction; Add water 160kg in reactor, in Extract at 70°C for 1.5 hours, filter, concentrate the filtrate to 20 L, and spray dry to obtain 7.5 kg of β-glycyrrhizinate monoammonium salt. After testing, the content was 75.2%.

Embodiment 2

[0026] Get content and be 30.1% beta glycyrrhizic acid raw material 30kg, pulverize, cross 160 mesh sieves, be placed in reactor; Pass into ammonia gas in reactor, stir reaction 2 hours, stop reaction; Add water 180kg in reactor, in Extract at 60°C for 1 hour, filter, concentrate the filtrate to 15 L, and boil and dry to obtain 9.8 kg of β-glycyrrhizinate monoammonium salt. After testing, the content was 88.1%.

Embodiment 3

[0028] Get content and be 25.5% beta glycyrrhizic acid raw material 40kg, pulverize, cross 80 mesh sieves, be placed in reactor; Pass into ammonia gas in reactor, stir reaction 6 hours, stop reaction; Add water 400kg in reactor, in Extract at 80°C for 2 hours, filter, concentrate the filtrate to 60 L, and spray dry to obtain 14.8 kg of β-glycyrrhizinate monoammonium salt. After testing, the content was 65.8%.

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Abstract

The invention provides a preparation method of beta-mono-ammonium glycyrrhizinate. According to the preparation method, the beta-mono-ammonium glycyrrhizinate is prepared by carrying out a series of steps such as crushing of beta-glycyrrhizic acid serving as a raw material, sieving, solid-state reaction, extracting, concentration and drying, and particularly utilizing a key technology that beta-glycyrrhizic acid powder can react with ammonia gas in a certain particle size range to generate the water-soluble beta-mono-ammonium glycyrrhizinate. Compared with a traditional preparation technology, the preparation method provided by the invention has very strong practicability and the advantages of energy conservation, environmental protection, low production cost and the like and is suitable for industrial production.

Description

technical field [0001] The invention provides a method for preparing β-glycyrrhizinate monoammonium salt, which belongs to the field of medicine and chemical industry. Background technique [0002] Licorice is a traditional Chinese medicine in China, which is recorded in the Chinese Pharmacopoeia. Licorice is the root and rhizome of Glycyrrhizauralensis Fisch., Glycyrrhiza inflata Bat., or Glycyrrhizaglabra L. of leguminous plants. It is mainly produced in Xinjiang, Inner Mongolia, Gansu and other places. my country is the largest production place of licorice in the world. At present, except for wild Glycyrrhiza licorice, artificially planted licorice has gradually been more and more widely used. As a commonly used traditional Chinese medicine, licorice has a long history of application. "Shen Nong's Materia Medica" listed it as the best medicine, and ancient medical scientists honored it as "the old man of the country". [0003] The main chemical component in licorice is g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00C07H15/256C07H1/00
Inventor 辛婷芬孙大伟郭杨军
Owner HUAIAN BROTHER BIOLOGICAL TECH
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