Tuning fork carotid bifurcate flow cavity and circulating system device

A circulatory system and carotid artery technology, applied in the field of biomechanics, can solve the problems of two-dimensional disturbance flow, time-consuming and labor-intensive, difference, etc., to achieve the effect of convenient disassembly and assembly

CN101930685AInactive Publication Date: 2010-12-29SHANGHAI JIAO TONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2010-12-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a tuning fork carotid bifurcate flow cavity and circulating system device in the technical field of biological engineering mechanics. The device consists of a flow cavity, a nutrient solution circulating system and a throttle valve, wherein the inlet of the flow cavity is connected with the nutrient solution circulating system; two outlets of the flow cavity are connected with the nutrient solution circulating system through the throttle valve respectively; and a cell culture window is embedded into the outside wall of the carotid sinus root of the flow cavity. Three-dimensional disturbance flow is realized on the cell culture window for simulating the wall shape of the outside disturbance area of the real carotid sinus root; the cell culture window is convenient to assemble and disassemble; and biological response of cultured cells to an approximately real arterial disturbance area environment can be quantitatively observed by using the flow cavity and the circulating system so as to provide a new tool for promoting atherosclerosis mechanical and biological research.
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Description

technical field

[0001] The invention relates to a device in the technical field of biomechanics, in particular to a tuning fork type human carotid bifurcation (TF-AHCB) flow chamber and circulation system device. Background technique

[0002] Clinical observation and autopsy found that the human carotid bifurcation is a typical atherosclerotic lesion. In the study of atherosclerotic lesions, the disturbed area of ​​the lateral wall of the root of the carotid sinus is the most studied site.

[0003] Biomechanical studies have confirmed that the flow in atherosclerotic lesions is a disturbed flow characterized by low shear stress distribution. Mechanobiological studies have shown that low shear stress disturbed flow may cause changes in active substances such as cell membrane receptors, signaling protein kinases, cytokines, and extracellular matrix, resulting in vascular reconstruction activities such as cell dedifferentiation, migration, hypertrophy, proliferation, and apopt...

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Embodiment Construction

[0022] The embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. This embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to the following the described embodiment.

[0023] The tuning fork type human carotid bifurcation flow cavity and the components of the circulatory system such as figure 1 Assembled as shown. figure 2 The inlet 6 in the tube is connected to the upper liquid storage bottle 2 through a silicone tube, and the outlet 7 is respectively connected to the restrictor 8 and the lower liquid storage bottle 3 through a silicone tube. The cell culture window is embedded in the cell culture module 12, and the cell culture module 12 is inserted into the flow cavity of the bifurcation of the human carotid artery of the tunin...