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Chinese medicinal composition and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its application, can solve the problems of uncontrollable quality, large dosage, inconvenience, etc., and achieve the effect of clear material basis of medicinal effect, excellent curative effect and small quality difference

Active Publication Date: 2013-05-22
EAST CHINA UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a traditional Chinese medicine composition and its application in order to overcome the shortcomings of traditional Yinchenhao Decoction, such as large dosage, inconvenient, and uncontrollable quality.

Method used

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  • Chinese medicinal composition and application thereof
  • Chinese medicinal composition and application thereof
  • Chinese medicinal composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1, the preparation of the medicine tablet for the treatment of liver disease

[0044] 1. Preparation of capillary extract

[0045] The capillary extract was prepared with reference to Chinese invention patent 101580447A: Accurately weigh 1.8kg capillary, add 32L ethanol with a volume percentage of 14% for reflux extraction, the extraction time is 1h, collect the extract; then add 32L to the residue The volume percentage is 14% ethanol for reflux extraction, the extraction time is 1 h, and the extract is collected. The two extracts were mixed, cooled to room temperature, filtered, and the filtrate was concentrated under reduced pressure until there was no alcohol smell to obtain 3 L of extract extract. Add ethanol with a volume percentage of 95% to the extract to adjust the alcohol content to 70%, let stand overnight, and filter. The filtrate was concentrated under reduced pressure to no alcohol smell, diluted with water to 2L, and then adjusted to pH 2.5 wi...

Embodiment 2

[0059] The preparation of embodiment 2 Chinese medicine composition of the present invention

[0060] Take the capillary extract dry powder, the gardenia extract dry powder, the rhubarb tannin extract dry powder, and the rhubarb polysaccharide extract dry powder in Example 1 and mix them in proportion, and use physiological saline to prepare 4 different concentrations. See Table 1 for the specific concentration of each extract in the component drug group solution and the four drug groups.

[0061] Table 1 DMN rat liver fibrosis model experimental drug composition (g / ml)

[0062] Group No

[0063] 2

Embodiment 3

[0064] Embodiment 3, the preparation of the medicine tablet for the treatment of liver disease

[0065] 1. Preparation of capillary extract

[0066] The capillary extract was prepared with reference to Chinese invention patent 101580447A: Accurately weigh 1.8kg capillary, add 20L ethanol with a volume percentage of 30% for reflux extraction, the extraction time is 0.5h, collect the extract; then add to the residue 32 L of 5% ethanol by volume was subjected to reflux extraction for 0.5 h, and the extract was collected. The two extracts were mixed, cooled to room temperature, filtered, and the filtrate was concentrated under reduced pressure until there was no alcohol smell to obtain 3 L of extract extract. Add ethanol with a volume percentage of 60% to the extract to adjust the alcohol content to 70%, let stand overnight, and filter. The filtrate was concentrated under reduced pressure to no alcohol smell, diluted with water to 2L, and then adjusted to pH 4 with 2mol / L hydroc...

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Abstract

The invention discloses a Chinese medicinal composition. The Chinese medicinal composition comprises the following components: a capillary wormwood herb extract, a cape jasmine fruit extract, a rhubarb extract I and a rhubarb extract II, and the weight (dry weight) ratio of the components is 1:0.2:0.2:0.2-1:10:15:15. The Chinese medicinal composition can effectively improve the indexes of liver function and relieve the extent of liver fibrosis, and has better curative effect compared with that of the compatibility prescriptions of raw medicinal materials; moreover, the components of the Chinese medicinal composition are definite, and the quality is easy to control.

Description

technical field [0001] The invention specifically relates to a traditional Chinese medicine composition and its application. Background technique [0002] Viral hepatitis is an infectious disease. There are about 120 million hepatitis virus carriers in China, and more than 30 million hepatitis patients. The proportion of hepatitis developing into liver fibrosis, liver cirrhosis and even liver cancer is very high, seriously affecting the life expectancy and quality of life of patients. In addition, the incidence of primary biliary cirrhosis and drug-induced liver disease is increasing. It can be seen that the development of drugs for the treatment of hepatobiliary diseases has important social significance. [0003] Yinchenhao Decoction was first recorded in Zhang Zhongjing's book "Treatise on Febrile Diseases" in the Han Dynasty: "Yangming disease, fever and sweating, this is heat, and it cannot turn yellow; but the head sweats, the body has no heat, and the neck is return...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61P1/16
Inventor 罗国安刘平胡坪王晓柠张敏周文君
Owner EAST CHINA UNIV OF SCI & TECH
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