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Traditional Chinese medicine composition with anti-hepatitis B and C virus activity

A technology of hepatitis C virus and composition, which is applied in antiviral agents, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of undiscovered reports of hepatitis C virus in rhubarb saltpeter soup, and improve the dependence , stable quality, easy to carry and take effect

Active Publication Date: 2017-07-04
阿南达
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, there is no report about the anti-hepatitis B virus and hepatitis C virus of rhubarb saltpeter soup

Method used

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  • Traditional Chinese medicine composition with anti-hepatitis B and C virus activity
  • Traditional Chinese medicine composition with anti-hepatitis B and C virus activity
  • Traditional Chinese medicine composition with anti-hepatitis B and C virus activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Take 2700g of gardenia, decoct and extract twice with water, add 32L of water for 1 hour each time, filter the decoction liquid while it is hot, combine the 2 times of decoction liquid, concentrate to 0.5g crude drug / mL, and load gardenia per mL of resin. 1.5g of the crude drug was loaded into HPD-100 macroporous resin, washed with water until clear, and then eluted with 75% ethanol until colorless, collected the ethanol eluent, recovered the solvent, dried at low temperature, and pulverized into fine powder to obtain 200g gardenia refined components.

[0044] Take 1800g of rhubarb, decoct and extract 3 times in water, add 18L of water each time and decoct for 0.5h, filter the decoction liquid while hot, combine 3 times of decoction liquid, concentrate to 0.75g crude drug / mL, and load rhubarb according to each mL of resin 0.94g of crude drug was loaded with AB-8 macroporous resin, washed with water until clear, and then eluted with 95% ethanol until colorless, collected...

Embodiment 2

[0049] Take 1350g of gardenia, decocted and extracted 3 times with water, add 13L of water each time and decocted for 1 hour, filter the decoction liquid while hot, combine the 3 times of decoction liquid, concentrate to 0.5g crude drug / mL, and load gardenia per mL of resin. 1.5g of the crude drug was loaded into HPD-100 macroporous resin, washed with water until clear, and then eluted with 75% ethanol until colorless, collected the ethanol eluent, recovered the solvent, dried at low temperature, and pulverized into fine powder to obtain 103g gardenia refined components.

[0050] Take 900g of rhubarb, decoct and extract twice with water, add 12L of water each time and decoct for 1 hour, filter the decoction liquid while hot, combine the 2 times of decoction liquid, concentrate to 0.75g crude drug / mL, and load crude rhubarb crude drug per mL of resin 0.94g of AB-8 macroporous resin was loaded, washed with water until clear, then eluted with 95% ethanol until colorless, collecte...

Embodiment 3

[0055] Take 270 g of gardenia, decoct and extract twice with water, add 3 L of water each time and decoct for 1 hour, filter the decoction liquid while it is hot, combine the 2 decoction liquids, concentrate to 0.5 g crude drug / mL, and load gardenia per mL of resin. 1.5g of the crude drug was loaded into HPD-100 macroporous resin, washed with water until clear, and then eluted with 75% ethanol until colorless, collected the ethanol eluent, recovered the solvent, dried at low temperature, and pulverized into fine powder to obtain 20g gardenia refined components.

[0056] Take 180g of rhubarb, decoct and extract twice with water, add 2L of water each time and decoct for 0.5h, filter the decoction liquid while hot, combine the 2 decoction liquids, concentrate to 0.75g crude drug / mL, and load rhubarb per mL of resin. The amount of crude drug 0.94g was loaded with AB-8 macroporous resin, washed with water until clear, then eluted with 95% ethanol until colorless, collected the etha...

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Abstract

The invention discloses a traditional Chinese medicine composition with anti-hepatitis B and C virus activity. The composition is prepared from the following medicinal raw materials in parts by weight: 4-15 parts of cape jasmine, 6-18 parts of rheum officinale, 6-18 parts of cortex phellodendri and 3-12 parts of mirabilite. Pharmacodynamic researches indicate that the traditional Chinese medicine composition can be used for well inhibiting expression of HBV genome stably transfected HepG2 cell line HBeAg and HBsAg antigens, achieves a certain effect of anti-HBV activity, can be used for remarkably inhibiting expression of Rluc in infected HCV (JFH1-luc) report virus Huh7.5.1 cell culture solution and reducing the content of HCV-RNA to show good anti-HCV activity, and indicates the treatment effect of inhibiting activity of hepatitis B and C viruses.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for viral hepatitis. The traditional Chinese medicine composition of the invention has activity for both hepatitis B and hepatitis C viruses. Background technique [0002] Hepatitis virus refers to the pathogen that causes viral hepatitis, including hepatitis A, B, C, D, E and other hepatitis viruses. Among them, hepatitis B and C viruses are mostly simultaneously or superimposedly infected with other types of hepatitis viruses, which is one of the main causes of chronic hepatitis, liver cirrhosis and liver cancer. [0003] my country is an area with a high incidence of hepatitis, and hepatitis diseases are on the rise year by year. Viral hepatitis ranks first among all types of hepatitis diseases, among which hepatitis B and C virus infections are the most common. It has the characteristics of high rate and difficult cure, which seriously threatens human health and life. [0004] Mod...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61P31/20A61P31/14A61P1/16A61K33/04
Inventor 裴妙荣孔祥鹏李慧峰
Owner 阿南达
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