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Modified polyethylene glycol superoxide dismutase (mPEG-SOD) nanoemulsion capable of being directly externally used for skin and preparation method thereof

A nanoemulsion and skin technology, applied in the field of medicine, can solve the problems of difficult to achieve therapeutic effect, low SOD penetration rate, etc., and achieve the effects of promoting transdermal absorption, solving low absorption rate and improving stability.

Active Publication Date: 2012-08-15
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the application of SOD skin administration, the transdermal rate of SOD is too low, and it can only partially enter the body through the skin, so it is difficult to achieve the therapeutic effect

Method used

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  • Modified polyethylene glycol superoxide dismutase (mPEG-SOD) nanoemulsion capable of being directly externally used for skin and preparation method thereof
  • Modified polyethylene glycol superoxide dismutase (mPEG-SOD) nanoemulsion capable of being directly externally used for skin and preparation method thereof
  • Modified polyethylene glycol superoxide dismutase (mPEG-SOD) nanoemulsion capable of being directly externally used for skin and preparation method thereof

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Embodiment 1

[0099] Embodiment 1: A kind of preparation method of the pegylated superoxide dismutase (mPEG-SOD) nanoemulsion that can directly skin external application

[0100] A preferred proportion by weight of each raw material of a pegylated superoxide dismutase (mPEG-SOD) nanoemulsion that can be directly used externally on the skin is:

[0101]

[0102]

[0103] A specific preparation method of a pegylated superoxide dismutase (mPEG-SOD) nanoemulsion that can be directly applied externally to the skin (taking the preparation of 100g as an example):

[0104] ① Preparation of mPEG-SOD aqueous solution: Dissolve 0.015g mPEG-SOD in 49.985g distilled water. This solution is used as the water phase (I) 50g;

[0105] ② Accurately weigh 7g of isopropyl myristate with an analytical balance, put it in another 50mL Erlenmeyer flask that has been decontaminated, and weigh 3g of vitamin E to dissolve it, and clearly mark it as the oil phase with a marker pen (II) 10g;

[0106] ③ Accurat...

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Abstract

The invention discloses modified mPEG-SOD nanoemulsion capable of being directly externally used for skin and a preparation method thereof. The mPEG-SOD nanoemulsion is prepared from the following raw materials in part by weight: 7 parts of isopropyl myristate, 30 parts of caprylocaproyl macrogolglycerides, 10 parts of polyglyceryl-3-dioleate, 50 parts of mPEG-SOD aqueous solution and 3 parts of vitamin E. The mPEG-SOD nanoemulsion solves the problem that the SOD has low stability, is easy to deactivate, and has poor penetrability for external application to the skin. The modified polyethylene glycol superoxide dismutase (mPEG-SOD) nanoemulsion capable of being directly externally used for the skin is a preparation with good stability and capacity of persistently protecting the bioactivity of the SOD, and can quickly penetrate the skin so as to greatly improve the biological effect of the SOD. The preparation method has the advantages of simple preparation process, easy actual operation, no need of special instrument and equipment, and high-efficiency and quick preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pegylated superoxide dismutase (mPEG-SOD) nanoemulsion which can be directly applied externally to the skin and a preparation method thereof. Background technique [0002] (1) Overview of SOD [0003] Since American scholars McCord and Fridovich first discovered and successfully extracted superoxide dismutase (SOD) from bovine red blood cells in 1968, the research and application of SOD has been popularized by researchers of different professions and disciplines in the world. focus on. People from different fields, different degrees, different scopes, and with different methods and means, research and discuss the chemical nature, biological characteristics, molecular structure, pharmacology, medicinal chemistry and clinical, pharmaceutical, and chemical engineering of SOD. , and successfully established a set of rapid and effective SOD separation and analysis methods. Especia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/44A61K8/66A61K8/86A61P17/00A61P39/00A61Q19/00
Inventor 杨永鹏朱晓亮董萍丁克祥左夏林丁宇
Owner 董萍