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Antithrombin preparation and preparation method thereof

An antithrombin and preparation technology, applied in the field of antithrombin preparations, can solve the problems of high production cost, heavy fishy odor, hindering blood coagulation and the like

Active Publication Date: 2014-09-24
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Modern pharmacological studies have shown that hirudin can prevent the action of thrombin on fibrinogen and hinder blood coagulation. However, due to the poor stability of hirudin, the transfer rate of active ingredients in medicinal materials is not high, resulting in a great waste of medicinal materials; production conditions The requirement is higher, and the storage condition of the finished product is a shady and cool warehouse, which makes the production cost larger, and the storage after transportation and purchase becomes a big problem; with the development of modern medical technology, the blood-sucking animal leech (Whitmania pigra Whitman), Hirudo nipponica Whitman, Whitmania acranulata Whitman, Poecilobdella manillensis, Dinobdella ferox, Haemadipsa japonicaWhitman, Haemadipsa sylvestris Blanchard ) research and application have also made a lot of significant progress, and the scope of treatment of diseases has also been expanded; at present, clinically, Maixuekang Capsules are made of leech animals, and the source of raw materials is limited, and they are dried and pulverized animals. All of them are used as medicine, because the stability of hirudin is not good, so the production conditions are relatively high, and the transfer rate of active ingredients in the medicinal materials is not high, resulting in a great waste of medicinal materials. The storage conditions of the finished products are shady and cool warehouses. Storage has become a big problem; in addition, Maixuekang capsules are crushed into whole animals and used as medicine. Because they are hard capsules and cannot be dissolved in gastric juice, the stench is heavy, which brings a lot of discomfort to patients.

Method used

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  • Antithrombin preparation and preparation method thereof
  • Antithrombin preparation and preparation method thereof
  • Antithrombin preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Preparation of raw drug powder: chop one or more of the frozen leech, leech or phenanthrene into small pieces, process it into a homogenate through a meat grinder, and add the homogenate at a ratio of 1:1.2 After the filler is mixed for 30 minutes, put the mixture in a drying oven, and dry it at a temperature ≤55°C and a vacuum degree ≥-0.09MPa. After drying, grind it to a size above 80 mesh, and then transfer it to a trough mixer for mixing; Adopt the Co60 radiation sterilization method to sterilize the bulk drug powder, and set aside;

[0121] Preparation of soft capsule contents: add weighed beeswax into soybean oil, heat until completely dissolved, and cool to temperature ≤ 45°C; add sterilized raw drug powder, mix well, and pass colloid mill 4 times; Add lecithin and mix evenly, pass through the colloid mill again, and set aside;

[0122] Preparation of enteric-coated soft capsules: Add pure water into the glue tank, turn on the stirring paddle, add glycerin and f...

Embodiment 2

[0124] Preparation of raw drug powder: chop one or more of the frozen leech, leech or phenanthrene into small pieces, process it into a homogenate through a meat grinder, and add the homogenate at a ratio of 1:1.2 After the filler is mixed for 30 minutes, put the mixture in a drying oven, and dry it at a temperature ≤55°C and a vacuum degree ≥-0.09MPa. After drying, grind it to a size above 80 mesh, and then transfer it to a trough mixer for mixing; Adopt the Co60 radiation sterilization method to sterilize the bulk drug powder, and set aside;

[0125] Preparation of soft capsule contents: add weighed beeswax into soybean oil, heat until completely dissolved, and cool to temperature ≤ 45°C; add sterilized raw drug powder, mix well, and pass colloid mill 4 times; Add lecithin and mix evenly, pass through the colloid mill again, and set aside;

[0126] Preparation of enteric-coated soft capsules: Add pure water into the glue tank, turn on the stirring paddle, add glycerin and g...

Embodiment 3

[0128] Preparation of raw drug powder: chop one or more of the frozen leech, leech or phenanthrene into small pieces, process it into a homogenate through a meat grinder, and add the homogenate at a ratio of 1:1.2 After the filler is mixed for 30 minutes, put the mixture in a drying oven, and dry it at a temperature ≤55°C and a vacuum degree ≥-0.09MPa. After drying, grind it to a size above 80 mesh, and then transfer it to a trough mixer for mixing; Adopt the Co60 radiation sterilization method to sterilize the bulk drug powder, and set aside;

[0129] Preparation of soft capsule contents: add weighed beeswax into soybean oil, heat until completely dissolved, and cool to temperature ≤ 45°C; add sterilized raw drug powder, mix well, and pass colloid mill 4 times; Add lecithin and mix evenly, pass through the colloid mill again, and set aside;

[0130] Preparation of enteric-coated soft capsules: Add pure water into the glue tank, turn on the stirring paddle, add glycerin and g...

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Abstract

The invention relates to an antithrombin enteric soft capsule preparation which is prepared by using part or all of leech, bloodsucker, whitmania acranulata Whitman, hirudinaria manillensis, dinobdella ferox, Haemadipsa japonica Whitman and Haemadipsa sylvestris as raw materials and other pharmaceutically acceptable auxiliary materials. The preparation method comprises the steps of: 1, preparing powder for preparation; 2, preparing contents in teh soft capsule; and 3, preparing the tenteric soft capsule. The preparation process for the enteric soft capsule preparation has the advantages of improving the stability, improving the transfer rate of effective components, lowering the production stroage requirements, reducing the process difficulty, and has the positive meanings on increasing the stability, quickening the development of the soft capsule preparations, improving the quality, and lowering the production cost.

Description

Technical field: [0001] The invention relates to an antithrombin preparation, in particular to an enteric-coated soft capsule of a natural thrombin inhibitor and a preparation method thereof. Background technique: [0002] Modern pharmacological studies have shown that hirudin can prevent the action of thrombin on fibrinogen and hinder blood coagulation. However, due to the poor stability of hirudin, the transfer rate of active ingredients in medicinal materials is not high, resulting in a great waste of medicinal materials; production conditions The requirement is higher, and the storage condition of the finished product is a shady and cool warehouse, which makes the production cost larger, and the storage after transportation and purchase becomes a big problem; with the development of modern medical technology, the blood-sucking animal leech (Whitmania pigra Whitman), Hirudo nipponica Whitman, Whitmania acranulata Whitman, Poecilobdella manillensis, Dinobdella ferox, Haema...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/62A61K47/36A61K47/38A61K47/42A61P7/02
Inventor 张观福萧钺
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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