Hydrosoluble reduced enzyme Q10 composition and preparation method thereof

A technology of reduction and composition, which is applied in the field of medicine, can solve the problems of unreported water-soluble reduced coenzyme Q10, etc., and achieve the effect of no suspension or precipitation, high stability and high solubility

Active Publication Date: 2011-02-09
杭州华东医药集团康润制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] However, none of the above patents have reported

Method used

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  • Hydrosoluble reduced enzyme Q10 composition and preparation method thereof
  • Hydrosoluble reduced enzyme Q10 composition and preparation method thereof
  • Hydrosoluble reduced enzyme Q10 composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Prepared by first dissolving reduced coenzyme Q10 in an organic solvent and then mixing it with an emulsifier:

[0035] Take 10g of reduced coenzyme Q10 and 20g of polyoxyethylene-40-stearate, dissolve in 20ml of ethyl acetate, stir to form a clear and transparent solution as a spare solution; take 1000ml of 50°C hot water, add 69g of pure gum and 1g Vitamin C, stir and dissolve under nitrogen atmosphere to make the solution clear, add the reserve solution at a drop rate of 0.35 ml / s, homogenize twice with a homogenizer at 80MPa and 160MPa, take it out after 20min each time, and put it in the air Spray drying under the drying parameters of 170°C and air outlet of 90°C, collect the spray powder and sieve to obtain the finished product.

[0036] The following is the performance test of the obtained water-soluble reduced coenzyme Q10 composition: the method for determining the content of the water-soluble reduced coenzyme Q10 composition mainly adopts high-performance liqu...

Embodiment 2

[0054] Prepared by direct heating and melting of reduced coenzyme Q10 and emulsifier:

[0055] Take 10g of reduced coenzyme Q10, 80g of pure gum, 30g of sucrose fatty acid ester and 0.5g of vitamin E, dissolve in 200ml of water, heat to 60°C to melt, and then use a homogenizer to homogenize twice at 100MPa and 180MPa, each time Take it out after 15 minutes, spray dry under the drying parameters of 170°C air inlet and 90°C air outlet, collect the spray powder and sieve to get the finished product.

[0056] The performance testing method of the obtained water-soluble reduced coenzyme Q10 composition is the same as that in Example 1.

[0057] 1. Stability test

[0058] The detection value of the water-soluble reduced coenzyme Q10 composition in this experiment is 0 under chromatographic conditions (C18 column, mobile phase: methanol: absolute ethanol = 1:1, detection wavelength 275nm), which proves that the water-soluble reduced coenzyme Q10 composition in this experiment The p...

Embodiment 3

[0074] Prepared by first dissolving reduced coenzyme Q10 in an organic solvent and then mixing it with an emulsifier:

[0075] Take 15g of reduced coenzyme Q10, 20g of sorbitol fatty acid ester and 20g of poloxamer, dissolve in 150ml of ethyl acetate, stir to form a clear and transparent solution as a spare solution; take 3000ml of hot water at 40°C, add 60g of lactose and 40g of Gum Arabic, stirring and dissolving to make the solution clear, add the reserve solution at a dropping rate of 0.5 ml / s, homogenize it with a homogenizer at 70MPa for 75 minutes, and take it out. Then spray dry, collect the spray powder and sieve to get the finished product.

[0076] The performance test method of the obtained water-soluble reduced coenzyme Q10 composition is the same as in Example 1, and the results are shown in Table 1, Table 2 and Table 3.

[0077] Table 1 shows that light has a greater impact on coenzyme Q10. The water-soluble reduced coenzyme Q10 composition in Example 3 of the...

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Abstract

The invention relates to a hydrosoluble reduced enzyme Q10 composition and a preparation method thereof, and provides a hydrosoluble reduced enzyme Q10 composition, which comprises raw materials and following mass components thereof: a reduced enzyme Q105-15, a hydrosoluble carrier 10-120, and an emulsifier 0.5-40; wherein the hydrosoluble carrier is one or more of maltose, CMC, gum rubber, soluble starch, lactose, fructose, sorbierite, mannitol, acacia and carrageenan; and the emulsifier is nonionic surfactant. The invention further provides the preparation method of the hydrosoluble reduced enzyme Q10 composition. In the method, the indissoluble reduced enzyme Q10 is mixed with the hydrosoluble carrier and the emulsifier to prepare the hydrosoluble reduced enzyme Q10 composition, advantages of an inclusion technology and a solid dispersion technology are synthesized, defects in the technologies are solved, a problem of slightly solubility of the reduced enzyme Q10 is solved, a series of tests shows that the reduced enzyme Q10 has water-solubility, high solubility, high dissolution rate, high stability and high active substance content.

Description

[0001] technical field [0002] The invention relates to the technical field of medicine, in particular to a coenzyme Q10 composition and a preparation method thereof. Background technique [0003] Coenzyme Q is an essential component widely distributed in organisms ranging from bacteria to mammals. The basic structure of coenzyme Q is 2, 3-dimethoxy-5-methylbenzoquinone nucleus containing isoprenoid side chains. Coenzyme Q in the human body contains ten such basic structures, namely coenzyme Q10, It was first isolated from bovine myocardium by Frederrick in 1957. It is known that in the human body, the side chain of coenzyme Q has 10 repeating structures, that is, coenzyme Q10 is the main component. Coenzyme Q10 (molecular formula C 59 h 90 o 4 ) is a physiological component that exists as a constituent component of the electron transport system of the mitochondria in the cells of a living body, and is repeatedly oxidized and reduced in the living body to function as ...

Claims

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Application Information

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IPC IPC(8): A61K38/00A61K31/05A61K47/40A61K31/355A61K31/09A61P3/02A61K31/375
Inventor 蒋风王维周建仁毛海明
Owner 杭州华东医药集团康润制药有限公司
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