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Method for preparing compound coenzyme medicine

A technology for coenzyme and API, applied in the field of dry medicine, can solve problems such as unfavorable mass production, complex preparation method, and single production process, and achieve the effects of being beneficial to mass industrial production, shortening the process flow, and simplifying the process flow

Inactive Publication Date: 2011-03-16
海南康永药品有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the disadvantages of complex preparation methods in the prior art, long processing time, high cost, and unfavorable mass production, and propose a new preparation method of a composite coenzyme. low, which is conducive to mass production, and the product quality is equivalent to that produced by the aforementioned patented method

Method used

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Embodiment Construction

[0028] Compound coenzyme drug preparation method embodiment 1, the method comprises the following steps:

[0029] 1) Melt with fresh frozen baker’s yeast stored at -5°C for one day and add 0.5 times pyrogen-free water;

[0030] 2) Use a high-pressure homogenizer to crush the yeast cells at a pressure of 50 MPa and a temperature of 10°C (in the range of a pressure of 50 to 150 MPa and a temperature of 0 to 20°C), or use a grinder to grind and crush the yeast cells;

[0031] 3) freeze and centrifuge the broken yeast cells at a temperature of 5°C and a centrifugal force of 15000G for 30 minutes to obtain a clarified centrifugate;

[0032] 4) ultrafiltration with an ultrafiltration column with a cut-off molecular weight of 8000 Daltons;

[0033] 5) adjusting the content of the effective components contained in the ultrafiltrate, so that the ultrafiltrate reaches the content standard of the drug, it is a compound coenzyme raw material drug;

[0034] 6) Add the corresponding manni...

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Abstract

The invention relates to a method for preparing compound coenzyme medicine and belongs to the technical field of medicine. The method comprises the steps of: adding pyrogen-free water in order to thaw fresh frozen yeast, smashing yeast cells by using physical method or mechanical method, refrigerating and centrifuging the smashed yeast cells, acquiring clear centrifuged solution, ultra-filtrating, and adjusting the content of the effective component in the ultra-filtrate, namely acquiring the compound coenzyme raw medicine, and adding in corresponding excipient or auxiliary material in order to make injected powder needle or oral-taken tablet or capsule. The invention not only increases the production efficiency but also lowers the production cost and ensures standard or over-standard content and quality of the effective component of the medicine.

Description

technical field [0001] The invention belongs to the technical field of dry medicine, and in particular relates to a new preparation method of a compound coenzyme drug. Background technique [0002] Compound coenzyme drugs are widely used in clinical medicine. In 2004, Beijing Aolute Biomedical Research and Development Co., Ltd., Beijing Suliman Biomedical Technology Co., Ltd. and Hainan Kangyong Pharmaceutical Co., Ltd. jointly applied for a patent "a preparation method of a compound coenzyme drug and its compound coenzyme drug and clinical application" , the patent number is ZL200410058086X. This patent discloses a preparation method of a new compound coenzyme drug and increases the composition of the compound coenzyme from only four kinds of coenzyme A, coenzyme I, ATP and glutathione to another containing FMN, FAD, ADP, AMP, There are nine kinds of SAM and so on. However, the preparation method of the invention is complicated, the processing time is long, and the cost ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/064A61P39/00
Inventor 林韶辉
Owner 海南康永药品有限公司
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