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Momestasone furoate cream and preparation method thereof

A technology of mometasone furoate cream and mometasone furoate, which is applied in the directions of ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve problems such as excessive hair growth, easy hardening of creams, and inducing acne, and achieves maintenance without loss. Water, smooth and delicate appearance, easy to apply effect

Active Publication Date: 2011-04-06
华润三九(南昌)药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the stability of mometasone furoate cream sold in the market is generally poor. After opening the mouth, the cream is easy to harden, the product quality changes, and the use effect is poor.
What's more, related reports have pointed out that certain mometasone furoate cream series products also have certain side effects, such as inhibition of the HAP axis, Cushing's syndrome caused by long-term heavy use, such as skin thinning , dilation of capillaries on the skin surface, and can cause skin relaxation, induce acne, cause hair follicle infection, excessive hair growth, skin allergic reactions, and may cause menstrual cycle disorders, etc.

Method used

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  • Momestasone furoate cream and preparation method thereof
  • Momestasone furoate cream and preparation method thereof
  • Momestasone furoate cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1, mometasone furoate emulsifiable paste, is made from the raw material of following weight ratio: 15 parts of mometasone furoate, 45 parts of cetearyl alcohol, 7.5 parts of glyceryl monostearate, 5 parts of beeswax , 35 parts of light liquid paraffin, 5 parts of sodium lauryl sulfate, 25 parts of propylene glycol, 1 part of ethylparaben, and the remaining amount of purified water to a total weight of 500 parts,

[0014] Wherein: the preparation method of mometasone furoate emulsifiable paste is: 1, oily phase: take cetearyl alcohol, glyceryl monostearate, beeswax, light liquid paraffin, paraben required for prescription quantity Mix and heat the ethyl ester to melt, heat it at 80-85°C for half an hour, pass through a 150-mesh sieve, and set aside; 2. Water phase: weigh the purified water required for the recipe and heat it to about 80°C, add dodecyl Stir the sodium sulfate to dissolve, pass through a 150-mesh sieve, keep warm at 80-85°C for half an hour, and...

Embodiment 2

[0015] Embodiment 2, mometasone furoate emulsifiable paste, is made from the raw material of following weight ratio: 15 parts of mometasone furoate, 45 parts of cetearyl alcohol, 7.5 parts of glyceryl monostearate, 5 parts of beeswax , 35 parts of light liquid paraffin, 5 parts of sodium lauryl sulfate, 25 parts of propylene glycol, 1 part of hydroxyethyl ester, add the remaining amount of purified water to a total weight of 500 parts,

[0016] Wherein: the preparation method of mometasone furoate emulsifiable paste is: 1, oil phase: take cetearyl alcohol, glyceryl monostearate, beeswax, light liquid paraffin, ethylparaben Mix and heat the esters to melt, keep warm at 80-85°C for half an hour, pass through a 150-mesh sieve, and set aside; 2. Water phase: weigh the purified water required for the recipe and heat it to about 80°C, then add dodecyl sulfuric acid Stir the sodium to dissolve, pass through a 150-mesh sieve, keep warm at 80-85°C for half an hour, and set aside; 3. Mi...

Embodiment 3

[0017] Embodiment 3, mometasone furoate emulsifiable paste, is made from the raw material of following weight proportion: 15 parts of mometasone furoate, 45 parts of cetearyl alcohol, 7.5 parts of glyceryl monostearate, 5 parts of beeswax , 8 parts of triethanolamine, 35 parts of light liquid paraffin, 2 parts of sodium lauryl sulfate, 8 parts of sodium lauryl sulfate, 25 parts of propylene glycol, 1 part of hydroxyethyl ester, 2 parts of Tween-802, and the purification of the remainder water to a total weight of 500 parts.

[0018] Wherein: the preparation method of mometasone furoate emulsifiable paste is: 1, oil phase: take cetearyl alcohol, glyceryl monostearate, beeswax, light liquid paraffin, ethylparaben Mix and heat the esters to melt, keep warm at 80-85°C for half an hour, pass through a 150-mesh sieve, and set aside; 2. Water phase: weigh the purified water required for the recipe and heat it to about 80°C, then add dodecyl sulfuric acid Stir sodium, sodium lauryl s...

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Abstract

The invention relates to the technical field of an external preparation medicament, in particular to an external preparation medicament containing momestasone furoate. The external preparation medicament is prepared from the following raw materials in part by weight: 15 parts of the momestasone furoate, 45 parts of hexadecyl-octadecyl alcohol, 7.5 parts of glyceryl monostearate, 5 parts of beeswax, 8 parts of triethanolamine, 35 parts of light liquid paraffin, 2 parts of sodium lauryl sulfate, 8 parts of sodium lauryl sulfate, 25 parts of propylene glycol, 1 part of Hydroxy acetate, 2 parts of tween-80, and the balance of purified water which is added to ensure that the total weight is 500 parts. The cream has better moisture retention and stability because the humectant combination of the triethanolamine and the propylene glycol is adopted.

Description

technical field [0001] The invention relates to the technical field of external preparations, in particular to an external preparation containing mometasone furoate. The cream has better moisture retention and stability due to the use of a humectant combination of triethanolamine and propylene glycol. sex. Background technique [0002] Mometasone furoate is a synthetic local glucocorticoid drug, which has the characteristics of strong curative effect and low inhibition of adrenal cortex function. Mometasone furoate cream has the effect of reducing inflammation and itching, suitable for skin diseases such as dermatitis (contact dermatitis, seborrheic dermatitis, atopic dermatitis, neurodermatitis) that are effective to glucocorticoids, acute, sub Acute and chronic eczema, discoid lupus erythematosus, lichen planus, skin amyloid lichenification, granuloma annulare, small area psoriasis, pretibial myxedema, etc. [0003] At present, the mometasone furoate cream sold in the ma...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/58A61K47/44A61P17/00A61P17/06A61K47/06
Inventor 李军吴泽榕徐玉琴曹员霞
Owner 华润三九(南昌)药业有限公司
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