Compound preparation for treating depression

A technology of compound preparations and inhibitors, which is applied in the field of compound preparations for the treatment of depression, can solve the problems of slow onset of antidepressant drugs, discomfort in long-term use, and elevated blood sugar, achieving good application prospects, prolonging the action time, and reducing elevated blood sugar levels. blood sugar effect

Inactive Publication Date: 2011-04-06
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a variety of medications are available, mainly antidepressants including non-selective reuptake inhibitors such as desipramine, imipramine, amitriptyline, monoamine oxidase inhibitors (MAOIs) such as phenelzine, and The third-generation antidepressants are selective serotonin reuptake inhibitors fluoxetine, sertraline, etc., but these drugs have different disadvantages that limit their use
The antidepressants of non-selective reuptake inhibitors have slow onset of action and many side effects, including the side effects of easily causing blood sugar elevation, which limit their use; and serotonin reuptake inhibitors, in addition to the above problems, are also expensive , not suitable for long-term use

Method used

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  • Compound preparation for treating depression
  • Compound preparation for treating depression
  • Compound preparation for treating depression

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Embodiment 1, desipramine and curcumin synergistically produce obvious depression effect and reduce the adverse reaction of the former to raise blood sugar

[0017] Male ICR mice, grade II, 20-25 g, were purchased from the Experimental Animal Center of Peking University Health Science Center. Breeding conditions: 10 birds / cage, room temperature 22±1°C, humidity 50±10%°C, natural light, free access to food and water. All animals were acclimatized in the feeding environment for 5 days before starting the experiment. Before the experiment, they were fasted for 12-16 hours and had free access to food and water. The 90 above-mentioned male mice were equally divided into 9 groups, 10 in each group: the specific grouping method was: one group of the control group was given an equal volume of normal saline; the desipramine and curcumin groups were respectively set according to the dosage One group of high, medium and low doses each, a total of six groups; the combination group...

Embodiment 2

[0027] Embodiment 2, the synergistic antidepressant effect of curcumin and fluoxetine

[0028]Male ICR mice, grade II, 20-25 g, were purchased from the Experimental Animal Center of Peking University Health Science Center. Breeding conditions: 10 birds / cage, room temperature 22±1°C, humidity 50±10%°C, natural light, free access to food and water. All animals were acclimatized in the feeding environment for 5 days before starting the experiment. Before the experiment, they were fasted for 12-16 hours and had free access to food and water. 80 above-mentioned male mice were equally divided into 8 groups, 10 in each group: the specific grouping method was: one group of the control group was given equal volume of normal saline; 10, 20, 30mg / kg body weight, three groups were established in the curcumin group, and the dosage of each group was 2.5, 5, 10mg / kg body weight respectively. One group was given curcumin and fluoxetine at a mass ratio of 1:4. Curcumin group was intragastri...

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PUM

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Abstract

The invention discloses a compound preparation for treating depression with the traditional antidepressant and curcumin as active components; the traditional antidepressant is a nonselective reuptake inhibitor or a selective 5-hydroxytryptamine reuptake inhibitor, wherein the nonselective reuptake inhibitor is desipramine, the selective 5-hydroxytryptamine reuptake inhibitor is fluoxetine, and the mass ratio of the traditional antidepressant to the curcumin can concretely be 2:1 or 4:1. In the compound preparation for treating the depression, low dosage curcumin and low dosage desipramine or fluoxetine are combined, thereby counteracting the adverse effects caused by blood sugar rise and displaying stronger antidepressant activity, and therefore, the compound preparation has good application prospect.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a compound preparation for treating depression. Background technique [0002] Depression and anxiety, a disease of the central nervous system, have become major diseases that threaten human health around the world. Although a variety of medications are available, mainly antidepressants including non-selective reuptake inhibitors such as desipramine, imipramine, amitriptyline, monoamine oxidase inhibitors (MAOIs) such as phenelzine, and The third-generation antidepressants are selective serotonin reuptake inhibitors fluoxetine, sertraline, etc., but these drugs have different disadvantages that limit their use. The antidepressants of non-selective reuptake inhibitors have slow onset of action and many side effects, including the side effects of easily causing blood sugar elevation, which limit their use; and serotonin reuptake inhibitors, in addition to the above problems, are also expensive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/12A61K31/55A61K31/138A61P25/24
Inventor 李学军胡敏铁璐潘燕高敏王瑞
Owner PEKING UNIV
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