Production process for reducing component B content of lincomycin

Abstract

The invention discloses a production process for reducing the component B content of lincomycin. The process method comprises: performing the absorption by macroporous resin on reverse extract of a solvent (including butanol or higher alcohol) extract, or aqueous solution of coarse lincomycin, or fermented filtrate of lincomycin or aqueous solution of recovered coarse lincomycin after pH adjustment by NaOH; washing by alkaline aqueous solution; desorbing with n-butyl alcohol; and producing finished products by normal processes. When the process method for reducing the component B content of lincomycin, which is provided by the invention, is used, the use amount of the alkaline aqueous solution for washing is lowered, the controllability of different requirements of users on the component B is improved, and the conventional process or equipment is improved; pollution caused to the environment is reduced greatly, the possibility for renewing waste water is increased; and the capacity ofabsorbing the reverse extract of the solvent extract of lincomycin is increased, the desorbing units are centralized, and at the same time, the labor intensity and production cost are reduced considerably and the large-scale industrial production can be realized easily.

Description

Technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to a production process for reducing the content of lincomycin B component. Background technique [0002] The traditional extraction process of lincomycin fermentation filtrate is extraction with solvent (butanol or higher carbon alcohol). Among them, when lincomycin is extracted with butanol, the B component content of the finished product is relatively high, which has great side effects in the clinical application of its derivatives, especially the large impact on intestinal, liver, and kidney functions; When extracting lincomycin, although the content of B component is reduced to a certain extent, the yield is not stable, the controllability of B component is not strong, and the production conditions and environmental conditions are all relatively poor, and it is easy to make the active pollution of its wastewater treatment However, when the tr...

AI Technical Summary

Problems solved by technology

Among them, when lincomycin is extracted with butanol, the B component content of the finished product is relatively high, which has great side effects in the clinical application of its derivatives, especially the large impact on intestinal, liver, and kidney functions; When extracting lincomycin, although the content of B component is reduced to a certain extent, the yield is not stable, the controllability of B component is not strong, and the production conditions and environmental conditions are all relatively poor, and it is easy to make the active pollution of its wastewater treatment However, when the traditional resin method is used for extraction, although the content of B component is reduced, the desorption unit is not concentrated, and the washing amount is large, resulting in an increase in production cost; especially when the solvent for lincomycin (including D Alcohol or higher carbon alcohol) during the adsorption and extraction of the back extract of the extract, the adsorption capacity of the resin is extremely small, and the desorption unit is tailed. At the same time, it is also difficult to reduce the lincomycin B component to less than 0.1%.