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Flavone C-glycoside extracted from boea hygrometrica and preparation method thereof

A technology of flavonoid glycosides and Capsula glycosides, which is applied in the field of flavonoid glycosides and its preparation, can solve problems such as extraction, and achieve the effects of convenient operation, huge economic and social benefits, and novel and unique preparation methods

Inactive Publication Date: 2011-04-13
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a kind of flavonoid carbon glycosides extracted from Capsula oleracea and its preparation method, which can effectively solve the problem of extracting flavonoid carbon glycosides from Capsule capsula. The problem

Method used

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  • Flavone C-glycoside extracted from boea hygrometrica and preparation method thereof
  • Flavone C-glycoside extracted from boea hygrometrica and preparation method thereof
  • Flavone C-glycoside extracted from boea hygrometrica and preparation method thereof

Examples

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Effect test

Embodiment 1

[0011] With 4.0kg of the whole herb of Henna-produced and dried, 4.0kg of the whole herb of Hesperia spp. was extracted three times with 50% acetone in a flash extractor at 23°C, each time for 18 minutes, with a mass concentration 10 times the weight of S. The extracts were combined, the solvent was recovered under reduced pressure at 45°C, and the dry powder was obtained after vacuum drying. The dry powder was dissolved in water and centrifuged. The deliquified flow is colorless, collect 10% methanol eluent, recover the solvent under reduced pressure, and vacuum dry to obtain 18.2g of dry powder, dissolve in water, centrifuge, put the supernatant on the gel Toyopearl HW-40C column, wash the column with water, The water flushing solution was obtained, and the water flushing solution passed through the gel Toyopearl HW-40C column, the gel Sephadex LH-20 column, the silica gel column, the MCI Gel CHP-20 column, and finally passed through the silica gel column to obtain yellow sol...

Embodiment 2

[0013] Extract 2.0kg of the whole herb of Dried Capsulatum from Yunnan or Guangxi in a flash extractor at 20°C with acetone that is 11 times the weight of Capsulatum and has a mass concentration of 50% for three times, each time for 20 minutes , combined the extracts, recovered the solvent under reduced pressure at 45°C, and obtained dry powder after vacuum drying. The dry powder was dissolved in water and centrifuged. The eluent flows out colorless, collects 10% methanol eluate, recovers the solvent under reduced pressure, and after vacuum drying, obtains 13.3g of dry powder, dissolves in water, centrifuges, puts the supernatant on the gel Toyopearl HW-40C column, and washes the column with water , to obtain the water flushing liquid, and the water flushing liquid passes through the gel Toyopearl HW-40C column, the gel Sephadex LH-20 column, the silica gel column, the MCI Gel CHP-20 column, and finally passes through the silica gel column to obtain the yellow solid 5,7 , 3'4'...

Embodiment 3

[0015] With 3.0kg of the whole herb of dried Capsula oleracea produced in Hunan or Sichuan, in a flash extractor at 25°C, extract three times with 50% acetone of 12 times the weight of Capsules capsulae weight, each time for 20 Minutes, combined the extracts, recovered the solvent under reduced pressure at 45°C, and obtained dry powder after vacuum drying. The dry powder was dissolved in water and centrifuged. When the eluent flows out colorless, collect 10% methanol eluent, recover the solvent under reduced pressure, and dry in vacuo to obtain dry powder 15.8g, dissolve it in water, centrifuge, put the supernatant on the gel Toyopearl HW-40C column, rinse with water Column, get water flushing liquid, water flushing liquid passes through gel Toyopearl HW-40C column, gel Sephadex LH-20 column, silica gel column, MCI Gel CHP-20 column successively, and finally passes through silica gel column again, obtains 5 of yellow solid, 7,3'4'-tetrahydroxy-6-methoxy-8-C-[β-D-xylose-(1→2)]-...

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Abstract

The invention relates to flavone C-glycoside extracted from boea hygrometrica and a preparation method thereof, which effectively solve the problem of extracting the flavone C-glycoside from the boea hygrometrica. The extracted flavone C-glycoside is 5,7,3'4'-tetrahydroxy-6-methoxy-8-C-[beta-D-xylose-(1-2)]-beta-D-glucose flavone C-glycoside. The preparation method comprises the following steps of: extracting the dried boea hygrometrica whole plant for three times by using acetone, mixing extract, recovering a solvent under reduced pressure, drying in vacuum to obtain dry powder, dissolving in water, centrifuging, loading supernatant to a macroporous adsorption resin column, washing the column by using methanol until eluent outflow is colorless, collecting methanol eluent, recovering a solvent under reduced pressure, drying in vacuum to obtain dry powder, dissolving in the water, centrifuging, loading supernatant to a gel column, washing the column by using the water to obtain water-washed liquid, and making the water-washed liquid pass through a gel Toyopearl HW-40C column, a gel Sephadex LH-20 column, a silica gel column, an MCI gel CHP-20 column and the silica gel column sequentially. The preparation method is novel, unique, advanced and scientific, is convenient to operate, and has high reliability and great economic and social benefits.

Description

1. Technical field [0001] The present invention relates to a kind of flavonoid carboglycoside extracted from Capsularia radiata and its preparation method. 2. Background technology [0002] Boea hygrometrica (Bunge.) R.Br. is the whole herb of Gesneriaceae Boea hygrometrica (Bunge.) R.Br., also known as cat's ear because of its leaf shape resembling a cat's ear. Perennial herb, the whole herb is used as medicine. It is widely distributed in Zhejiang, Fujian, Jiangxi, Guangdong, Guangxi, Hunan, Hubei, Henan, Shandong, Hebei, Liaoning, Shanxi, Shaanxi, Sichuan and Yunnan. Capsule moss has the effects of promoting blood circulation, dispelling blood stasis, and stopping bleeding. It is commonly used in folks to treat bruises, overworked low back pain, blood stasis, traumatic bleeding, and otitis media. Modern pharmacological studies have shown that it has various pharmacological activities such as antibacterial and anti-inflammatory, but there is no research report on its che...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08
Inventor 冯卫生郑晓珂李原京
Owner HENAN UNIV OF CHINESE MEDICINE
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