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Compositions comprising ARNOX-inhibitors for the inhibition of reactive oxygen species

A kind of composition, inhibitor technology, applied in the field of natural product extract

Inactive Publication Date: 2011-04-13
NU SKIN INT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most cosmetic or medical products do not address the root causes of these symptoms, such as the production and accumulation of arNOX-related free radicals from ROS

Method used

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  • Compositions comprising ARNOX-inhibitors for the inhibition of reactive oxygen species
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  • Compositions comprising ARNOX-inhibitors for the inhibition of reactive oxygen species

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Characterization of Narcissus Extract

[0119]To test the hypothesis that narcissus may have arNOX inhibitors, bulbs of pure white narcissus (Narcissus tazetta) were obtained from a supplier (Brent and Becky's Bulbs, Gloucester, VA). Aqueous and alcoholic extracts that inhibited arNOX activity and enhanced inhibition when combined with low activity Narcissus powder (Xian Aojing Science and Technology Development CO., LTD, Xian, China) were prepared. The enhancement of powder from narcissus bulbs with SHAM (Sigma-Aldrich, St. Louis, MO) is shown in Figure Ia. The ability of naractins to enhance arNOX inhibition was determined by following the same protocol, but applying salicin (Sigma-Aldrich) and narcissus powder (Xian Aojing Science and Technology Development CO., LTD, Xian, China) from flowers to enhance arNOX Inhibition, Figure 1b. Comparison was made to similar extracts of Narcissus pseudo-narcissus (Daffodils) and Narcissus jonquilla (Jonquilla) extracts lacking ...

Embodiment 2

[0122] Identification of arNOX inhibitors

[0123] To answer the question of whether the salicylic acid moiety that stabilizes salicyl hydroxamate is important for the inhibition of arNOX activity, salicylic acid (Naractin 2) was tested as an inhibitor of salivary arNOX activity in a 72-year-old male and found to inhibit arNOX activity ( Figure 8 ). Salicylic acid also appears red when reacted with ferric iron, similar to that exhibited by hydroxamates. Salicylates and / or aspirin did not inhibit arNOX activity. Aqueous extracts of willow bark, a natural source of salicylates, were tested and found to also inhibit arNOX. The glycoside salicin (Naractin 3), the major salicylate of willow bark, was subsequently also tested and found to be active at concentrations 10-fold lower than SHAM (Naractin 1) or salicylic acid (Naractin 2) ( Figure 9 ).

Embodiment 3

[0125] Identification of Salicylate-Producing Plants

[0126]Research was conducted to identify plants that are natural producers of salicylates. The study was conducted using the Natural Products database (available at napralert.org) created by Prof. Norman Farnsworth at the University of Illinois in Chicago. The study identified the following salicylate-producing plants in different identified tissues: A. chinense (Alangiaceae) Chinese dried leaves, A. chinense (Illiciaceae) Japanese dried leaves (cult), A. platanifolium (Illiciaceae) French dried leaf, A.platanifolium var.platanifolium (Illiciaceae) Japanese dried leaf, A.platanifolium var.trilobum (Illiciaceae) Japanese dried leaf, A.platanifolium var.trilobum (Illicaceae) Japanese dried leaf, A. premnifolium (Acarinaeceae) Japanese leaf, A. premnifolium (Illicaceae) Japanese stem, Aspergillus niger (hyphomycetes) Korean culture filtrate, betula alba (Birch family (betulaceae) German dry bark, Bupleurum falcatum (Apiacea...

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Abstract

The invention relates to agents for sequestering serum aging factors, and methods for using the same. More particularly, the invention relates to agents termed herein 'Naractin' to denote any one of several naturally-occurring arNOX inhibitors either present in N. tazetta powder or capable of augmenting N. tazetta powder to an inhibitory level comparable to that of the fresh N. tazetta extracts, and to methods for using 'Naractins' to prevent or treat disorders and complications of disorders resulting from cell damage caused by an aging-related isoform of NADH oxidase (arNOX). In one exemplary embodiment the agents of the invention comprise at least one naturally occurring Naractin. Such naturally occurring naratins are also capable of augmenting the anti-arNOX effect of other naturally occurring arNOX inhibitory agents.

Description

field of invention [0001] The present invention relates to natural product extracts for sequestering serum senescence factors which can be administered internally or topically. More specifically, the present invention relates to agents and compositions thereof for cosmetically inhibiting or improving aging-related oxidation, and methods for their use as skin care products. Background of the invention [0002] Plasma membrane NADH oxidase (NOX) is a unique cell surface protein with hydroquinone (NADH) oxidase and protein disulfide-thiol exchange activity that normally responds to hormones and growth factors. NOX (or CLOX) is a family of growth-associated proteins associated with senescent cells. A hormone-insensitive and drug-responsive form of NOX, designated tNOX, has been described, which form is specific for cancer cells. See, eg, US Patent No. 5,605,810, which is hereby incorporated by reference in its entirety. [0003] The aging-associated isoform of NADH oxidase (a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K31/609A61K31/60A61K31/166A61K36/896A61P17/00
CPCA61K31/7034A61K31/60A61K31/166A61K31/609A61P17/00A61K8/9789A61K8/368A61K8/42A61K8/602A61K36/355A61Q19/00A61Q19/08
Inventor D·克恩C·梅多斯
Owner NU SKIN INT
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