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Protective agent for nano-emulsion

A technology of nanoemulsion and protective agent, which can be applied in the direction of emulsion transportation, etc., can solve the problems of drug repackaging and unqualified drug quality.

Inactive Publication Date: 2011-04-20
HEBEI AOXING GROUP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the crystallization phenomenon occurs, even if the temperature is increased, the drug cannot be re-encapsulated in the nanoemulsion, which will cause the quality of the drug to be unqualified

Method used

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  • Protective agent for nano-emulsion
  • Protective agent for nano-emulsion
  • Protective agent for nano-emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016]

[0017]

[0018] Accurately weigh 3g of ibuprofen, add it to medium-carbon chain triglycerides, warm to dissolve, then add polyoxyethylene hydrogenated castor oil and glycerin, mix well, add 20ml of purified water, stir to make it a nanoemulsion, and set aside.

[0019] Weigh 50g of sucrose and dissolve it in 25ml of purified water.

[0020] Then slowly add the sucrose aqueous solution into the prepared nanoemulsion, stir evenly, and set aside.

Embodiment 2

[0022]

[0023] Accurately weigh 3g of ibuprofen, add it to the medium carbon chain triglyceride, warm to dissolve, then add polyoxyethylene hydrogenated castor oil and glycerin, mix well, slowly add purified water, stir to make it into a nanoemulsion, add purified Water to 100ml, set aside.

Embodiment 3

[0025]

[0026] Accurately weigh 2g of ibuprofen, add it to medium-carbon chain triglyceride, warm to dissolve, then add polyoxyethylene hydrogenated castor oil and glycerin, mix well, slowly add purified water, stir to make it into a nanoemulsion, add purified Water to 100ml, set aside.

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Abstract

The present invention provides a protective agent for nano-emulsion, which can improve the drug loading of nano-emulsion and the stability of nano-emulsion. Adding the protective agent into nano-emulsion can improve the drug loading of nano-emulsion. The influence factor of the preparation being investigated, no medicinal crystallization occurs when the nano-emulsion is in the refrigerated condition even in the freezing condition, and therefore the invention can not only improve the quality of medicine but also in favor of the storage and transportation of medicine.

Description

field of invention [0001] The invention relates to a nanoemulsion protective agent and its application. Background technique [0002] Nanoemulsion is a uniform oil-in-water liquid preparation formed by oil phase, emulsifier, co-emulsifier, and water. The particle size of the formed emulsion is nanometer level. After the drug is made into nanoemulsion, it can effectively mask the bitter taste of the drug, and at the same time It can effectively increase the contact area between the drug and the gastrointestinal tract, thereby improving drug dissolution and bioavailability. [0003] Conventionally, nanoemulsions are isotropic transparent liquids, which are thermodynamically stable systems, and cannot be separated by autoclaving or centrifugation. But sometimes under refrigerated and frozen conditions, because the solubility of the drug in the nanoemulsion in the liquid oil phase decreases with the decrease of temperature, crystallization will occur. After the crystallization...

Claims

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Application Information

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IPC IPC(8): A61K47/26A61K9/107
Inventor 刘福利赵晓雷杨丽英滑千里王乃浩
Owner HEBEI AOXING GROUP PHARMA
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