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Composite capsule containing telmisartan and calcium ion channel antagonist

A technology of calcium ion channel and telmisartan, applied in the field of compound capsules, can solve the problems of reduced stability of amlodipine, difficulty in realizing compound capsules and the like

Inactive Publication Date: 2011-04-27
邓俐丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] CN200580033928.9 discloses a double-layer tablet containing telmisartan and amlodipine, which describes in detail the method for preparing a double-layer tablet containing telmisartan and amlodipine. In this patent, it is considered that by physical Separation of the two components is necessary as direct mixing of the two results in reduced stability of amlodipine
And think that it is difficult to realize the preparation of the two components into compound capsules

Method used

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  • Composite capsule containing telmisartan and calcium ion channel antagonist
  • Composite capsule containing telmisartan and calcium ion channel antagonist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 Preparation of granules containing telmisartan

[0028] The required materials and dosage are shown in Table 3.

[0029] table 3

[0030] Telmisartan

[0031] Dissolve poloxamer 188 and povidone K-30 in an appropriate amount of ethanol for later use, mix telmisartan, microcrystalline cellulose, meglumine, and sodium carboxymethyl starch evenly, and then add the above ethanol solution to prepare After mixing evenly, granulate, dry at 60°C, after granulation, add magnesium stearate, and mix evenly.

Embodiment 2

[0032] Embodiment 2 Preparation of small tablets containing amlodipine besylate

[0033] The required materials and dosage are shown in Table 4.

[0034] Table 4

[0035] Amlodipine

[0036] Sodium carboxymethyl starch

[0037] Mix amlodipine besylate, calcium hydrogen phosphate anhydrous, microcrystalline cellulose, and sodium carboxymethyl starch evenly, use povidone K-30 ethanol solution as a binder to granulate, dry at 60°C, and granulate Finally, add magnesium stearate, mix evenly, press into discs with a diameter of 4.5 mm, and film-coat to obtain.

Embodiment 3

[0038] Embodiment 3 Preparation of small tablets containing levamlodipine besylate

[0039] The required materials and dosage are shown in Table 5.

[0040] table 5

[0041] Levoamlodipine Besylate

[0042] Take levamlodipine besylate, anhydrous calcium hydrogen phosphate, microcrystalline cellulose, and sodium carboxymethyl starch and mix evenly, use the ethanol solution of povidone K-30 as a binder to granulate, dry at 60°C, and prepare After granulation, magnesium stearate is added, after mixing evenly, it is compressed into discs with a diameter of 4.5 mm, and coated with a film coating.

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Abstract

The invention discloses a composite capsule containing telmisartan and a calcium ion channel antagonist, which is prepared by filling the first part containing the telmisartan and the second part containing the calcium ion channel antagonist into the same hollow capsule, wherein the physical isolation is formed between the two parts through filming. Therefore, the composite capsule has the purposes of preparing the calcium ion channel antagonist with the appropriate size containing the telmisartan and the calcium ion channel antagonist and simplifying the preparation process thereof. The composite capsule has the advantages of appropriate size and is convenient in administration, and the preparation method is suitable for automatic capsule fillers after the appropriate improvement.

Description

technical field [0001] The invention is a compound capsule, which is composed of a first part containing telmisartan and a second part containing a calcium ion channel antagonist filled in the same hollow capsule, and the two parts are physically separated by a film coating. Background technique [0002] Telmisartan, as disclosed in EP-A-502314, is an angiotensin receptor inhibitor and is clinically used to treat mild to moderate hypertension. Its chemical name is 4'-[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-ylmethyl]link Phenyl-2-carboxylic acid, having the following structural formula: [0003] [0004] Telmisartan is a white or off-white crystalline powder, almost soluble in water, and its alkali metal salt is easily soluble in water and alcohol. When preparing a pharmaceutical preparation, it is added in a free form, and the auxiliary material contains at least one basic reagent. Since there is no tetrazole ring contained in other sarta...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K45/00A61K31/4422A61P9/12A61K31/4184
Inventor 邓俐丽
Owner 邓俐丽