Medicinal composition for treating acne

A gel composition, acne technology, applied in the directions of drug combination, drug delivery, hydroxyl compound active ingredients, etc., can solve problems such as limiting the selection of gel agents, and achieve the effects of reducing irritation, avoiding inconvenience, and improving contact time

Active Publication Date: 2011-05-04
SUNSHINE LAKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Patent CN02825846.0 chooses a PH-independent gel to solve this problem, but it greatly lim

Method used

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  • Medicinal composition for treating acne
  • Medicinal composition for treating acne
  • Medicinal composition for treating acne

Examples

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Embodiment Construction

[0041] The following examples illustrate the present invention in detail, and the protection scope of the present invention is not limited to the following examples.

[0042] One, preparation prescription embodiment

[0043] Prescription 1 (prescription without antioxidants)

[0044] Retinoic Acid 0.1%, Benzoyl Peroxide 5%, Polycarbophil 0.5%, Glycerin 10%, Propylene Glycol 5%, Disodium Lauryl Sulfosuccinate Monoester 2%, Methylparaben 0.2%, Add 0.08% propylparaben, 0.2% benzalkonium chloride, 0.25% triethanolamine, and purified water to 100%.

[0045] Prescription 2

[0046] Retinoic Acid 0.1%, Benzoyl Peroxide 5%, Polycarbophil 0.5%, Glycerin 10%, Propylene Glycol 5%, EDTA-2Na 0.4%, Disodium Lauryl Sulfosuccinate Monoester 2%, Paraben Add gold methyl ester 0.2%, propylparaben 0.08%, benzalkonium chloride 0.2%, triethanolamine 0.25%, and purified water to 100%.

[0047] Prescription 3

[0048] Tretinoin 0.1%, Benzoyl Peroxide 5%, Polycarbophil 0.5%, Glycerin 10%, Propyle...

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Abstract

The invention relates to a gel composition for treating acne, which comprises the following components in percentage by weight: 0.01 to 20 percent of at least of a retinoic acid active component, 0.01 to 20 percent of diphenylperoxyanhydride, 0.1 to 10 percent of at least one high polymer gel and 0.1 to 4 percent of antioxygen, wherein the antioxygen may be one or more of butylated hydroxytoluene (BHT), ethylenediaminetetraacetic acid-2 (EDTA-2), Na, butylated hydroxyanisole (BHA), vitamin E, vitamin E acetate and vitamin E nicotinate. The composite antioxygen used in the invention can effectively solve the chemical and physical stability problems of retinoic acid and diphenylperoxyanhydride composite preparation, and it is found that the antioxygen has good chemical and physical stabilizing effect on common gel systems, greatly improves the gel selection range, recues cost, simplifies operation steps and effectively controls product quality.

Description

technical field [0001] The invention relates to an aqueous gel for treating acne containing retinoic acid and benzoyl peroxide and a related method for preparing the aqueous gel. Background technique [0002] Acne, also known as acne, pimples or acne, folliculitis, is a skin disease caused by blockage and inflammation of hair follicles and sebaceous glands. It is very common to use retinoic acid alone to treat acne. Epidermal keratinocytes, melanocytes and dermal fibroblasts are all important target cells for the action of retinoic acid. Benzoyl peroxide is also one of the most widely used drugs for treating acne. The mechanism of action of benzoyl peroxide is not completely clear, but it is believed that it is mainly due to its bactericidal ability to Propionibacterium acnes. Formyl-treated patients showed decreased lipids and free fatty acids and mild desquamation with reduced comedones and acne lesions. Retinoic acid or benzoyl peroxide is usually combined with clindamy...

Claims

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Application Information

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IPC IPC(8): A61K31/327A61K31/203A61K9/00A61P17/10
Inventor 马廉正周海波
Owner SUNSHINE LAKE PHARM CO LTD
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