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Application of aucubin to preparation of anti-thrombosis medicament

A technology of aucubin and thrombus is applied in the field of drug preparation, which can solve problems such as undiscovered, and achieve the effects of preventing thrombosis, high safety and inhibiting blood coagulation.

Inactive Publication Date: 2012-06-27
BIOLOGY INST OF SHANDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no literature report that related aucubin has the effect of inhibiting platelet aggregation caused by ADP

Method used

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  • Application of aucubin to preparation of anti-thrombosis medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A drug for preventing thrombosis with aucubin as the active ingredient, containing the following components per 100g:

[0045] Aucubin 50 grams, pregelatinized starch 49 grams, micronized silica gel 0.5 grams, magnesium stearate 0.5 grams.

[0046] The above-mentioned drugs are sieved and mixed evenly, and filled into capsules of 100 mg / capsule.

Embodiment 2

[0048] A drug for preventing thrombosis with aucubin as the active ingredient, containing the following components per 100g:

[0049] 50 grams of aucubin, 37.5 grams of starch, 3 grams of povidone, 4 grams of mucilage (guar gum), 5 grams of mannitol, 0.5 grams of magnesium stearate, mix well, and control the particle size to 35-80 μm, Directly compress the tablet to obtain 1000 compressed tablets of aucubin.

Embodiment 3

[0050] Example 3: Effect of aucubin on arteriovenous bypass thrombosis in rats

[0051] Take 50 SD rats, half male and half male, weighing 200-300 grams. According to body weight, they were randomly divided into 5 groups, 10 in each group. The first group was injected with an equal volume of normal saline from the tail vein. The second group was injected with 100mg / kg aspirin from the tail vein. Groups 3-5 were injected with 50, 100, and 200 mg / kg aucubin from the tail vein respectively. After 15 minutes, they were anesthetized with pentobarbital sodium 30 mg / kg, fixed in a supine position, and the common carotid artery of one side of the rat and the external jugular vein of the other side were surgically separated, and a 6 cm long F4 surgical thread was placed in a polyethylene tube. Fill the polyethylene tube with 50000U / L heparinized saline, then insert one end of the polyethylene tube into the left external jugular vein, then insert the other end of the tube into the ri...

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Abstract

The invention relates to the application of aucubin to the preparation of an anti-thrombosis medicament, and discloses the application of the aucubin to the preparation of the anti-thrombosis medicament and the anti-thrombosis medicament taking the aucubin as an active ingredient, which belong to the technical field of medicament preparation. The medicament comprises the following components in part by weight: 10 to 99 parts of aucubin and 1 to 90 parts of pharmaceutically acceptable carrier. In the invention, researches show that the aucubin has an effect on the suppression of platelet aggregation caused by adenosine diphosphate (ADP), and the application is different from the conventional reported use of the aucubin. A new way for preventing and treating thrombosis caused by the platelet aggregation is provided.

Description

technical field [0001] The invention relates to the application of aucubin in the preparation of medicines for preventing thrombosis, and belongs to the technical field of medicine preparation. Background technique [0002] The incidence of thrombotic diseases is increasing year by year, how to carry out effective prevention, diagnosis and treatment has attracted widespread attention at home and abroad. In the cardiovascular system of the living body, the process of coagulation of blood or the formation of certain substances in the blood, which coagulates to form solid masses, is called thrombus formation (thrombosis). Unlike blood clots, thrombi are formed in the state of blood flow, which is abnormal coagulation due to activation of platelets and activation of coagulation factors. The conditions of thrombus formation are currently recognized as three conditions proposed by Virchow: vessel wall damage (including mechanical damage and endothelial cell dysfunction, etc.), bl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P7/02A61P9/10A61P11/00
Inventor 何秋霞刘可春陈锡强韩利文彭维兵袁延强
Owner BIOLOGY INST OF SHANDONG ACAD OF SCI