Equipment and method for preparing uniform dripping pills

A dripping pill and uniform technology, which is applied in the direction of making medicine into a special physical or taking form of the device, can solve the problems of low production capacity and large difference in pill weight, etc., and achieve high product efficiency, reduce waste rate, and roundness Good effect of sex and uniformity

Inactive Publication Date: 2011-06-01
TIANJIN UNIV
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  • Description
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AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a device and method for preparing uniform dripping pills by using vibration to disperse the jet of molten medicinal liquid into uniform droplets for the shortcomings of the prior art, such as low production capacity and large difference in pill weight. Precise control can be carried out again, and production capacity can be greatly improved

Method used

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  • Equipment and method for preparing uniform dripping pills
  • Equipment and method for preparing uniform dripping pills

Examples

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Embodiment 1

[0033] The drug is nifedipine, the auxiliary materials are polyethylene glycol (PEG) 4000 and (PEG) 6000, the ratio of the two is 5:1, and the ratio of the auxiliary materials to the drug is 5:1. The height of the cooling column is 2m, and dimethyl silicone oil is used as the cooling liquid. The upper part of the cooling column is set at 120°C, the middle part is room temperature, and the lower part is 5°C. When the nozzle diameter is 0.3mm, the number of nozzles is 3, and they are arranged in an equilateral triangle, the pressure of the molten chemical liquid is 0.05MPa, the jet velocity at the nozzle is about 1.6m / s, the set temperature is 135°C, and the vibration frequency is set to 200Hz, the amplitude is 0.15mm, and the diameter of the prepared dripping pills is 1.5mm ± 0.05mm, and the dripping pills account for 98% of the total mass; The hydraulic pressurization is 0.06MPa, and the jet flow velocity of the orifice at the nozzle is about 1.8m / s. The temperature is set at...

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Abstract

The invention discloses equipment and method for preparing uniform dripping pills. The equipment comprises a melting tank 2, a feeding pipeline 5, a flow sensor 7, a nozzle 15, a vibrator, a cooling column 16 and a dripping pill collector 18, wherein the melting tank 2 is sequentially connected with a valve 6, the flow sensor 7 and the nozzle 15 through the feeding pipeline 5; the vibrator comprises a signal generator 9, a power amplifier 10 and a vibration exciter 11; the signal generator 9 is sequentially connected electrically with the power amplifier 10 and the vibration exciter 11; the vibration exciter 11 is connected with the nozzle 15 through a connecting rod 14; the cooling column 16 is installed under the nozzle 15; cooling liquid 17 is filled in the cooling column 16; and the dripping pill collector 18 is arranged at the bottom in the cooling column 16. The dripping pill product produced by the equipment disclosed by the invention has good roundness and uniformity, the rejection rate can be reduced, the product quality can be improved, and the granularity and weight of the prepared product can be regulated in an on-line mode by changing vibration frequency, flow rate and other conditions.

Description

technical field [0001] The invention relates to a device and a method for preparing uniform dripping pills. technical background [0002] Dropping pills are one of the mature dosage forms of solid dispersions. Compared with traditional preparations, they have incomparable advantages in preparation and drug release, and conform to the "three small", "three effects" and "five conveniences" of modern pharmaceutical preparations. "Basic requirements. The preparation of existing dripping pills is to melt or dissolve solid or liquid medicines and suitable auxiliary materials into solutions, suspensions or emulsions, and then drop them into immiscible condensate to obtain. The output is limited by the dropping speed. limits. [0003] The methods used in the preparation of drop pills are mainly natural drop method and pulse cutting method. Among them, the natural drop method is not suitable for liquid medicines that are too thick, too thin, or have low surface tension. The pill w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/06
Inventor 范江洋陈松李国兵王彦兵
Owner TIANJIN UNIV
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