Equipment and method for preparing uniform dripping pills
A dripping pill and uniform technology, which is applied in the direction of making medicine into a special physical or taking form of the device, can solve the problems of low production capacity and large difference in pill weight, etc., and achieve high product efficiency, reduce waste rate, and roundness Good effect of sex and uniformity
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[0033] The drug is nifedipine, the auxiliary materials are polyethylene glycol (PEG) 4000 and (PEG) 6000, the ratio of the two is 5:1, and the ratio of the auxiliary materials to the drug is 5:1. The height of the cooling column is 2m, and dimethyl silicone oil is used as the cooling liquid. The upper part of the cooling column is set at 120°C, the middle part is room temperature, and the lower part is 5°C. When the nozzle diameter is 0.3mm, the number of nozzles is 3, and they are arranged in an equilateral triangle, the pressure of the molten chemical liquid is 0.05MPa, the jet velocity at the nozzle is about 1.6m / s, the set temperature is 135°C, and the vibration frequency is set to 200Hz, the amplitude is 0.15mm, and the diameter of the prepared dripping pills is 1.5mm ± 0.05mm, and the dripping pills account for 98% of the total mass; The hydraulic pressurization is 0.06MPa, and the jet flow velocity of the orifice at the nozzle is about 1.8m / s. The temperature is set at...
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