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Injection for preventing and treating porcine viral diseases and preparation method thereof

A viral disease and injection technology, applied in antiviral agents, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems affecting the use effect, achieve convenient clinical use, less dosage, and less bacterial contamination Effect

Inactive Publication Date: 2012-11-28
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of interferon alone to treat viral diseases requires long-term use of large doses to be effective, and long-term use of large doses of interferon is prone to side effects, and even induces the body to produce anti-interferon antibodies, affecting the subsequent use effect

Method used

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  • Injection for preventing and treating porcine viral diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] An injection for preventing and treating porcine viral diseases, containing 1 g of thymopentin and 1 × 10 alpha interferon in every 1000 ml of the injection 8 IU, gentamicin sulfate 50 million units, sodium edetate 0.1g, human serum albumin 0.2g, 5mmol / l citric acid-sodium citrate buffer 50ml, 0.75% (m / v) chlorine NaCl solution 20ml, sodium hydroxide and the rest of the water for injection.

[0016] Take each raw material during preparation, then add thymopentin, alpha interferon, gentamicin sulfate, sodium edetate, human serum albumin, citric acid-sodium citrate buffer, and sodium chloride solution into 600ml for injection Dissolve in water; adjust the pH value to 6.5 with sodium hydroxide, and add water for injection to 1000ml.

Embodiment 2

[0018] An injection for preventing and treating porcine viral diseases, containing 50 g of thymopentin and 5×10 interferon beta in every 1000 ml of the injection 8 IU, gentamicin sulfate 30 million units, sodium metabisulfite 1g, polyethylene glycol 0.3g, 30mmol / l acetic acid-sodium acetate buffer 80ml, 5% (m / v) glucose solution 50ml, pH regulator and other amount of water for injection.

[0019] Take each raw material during preparation, then add thymopentin, beta interferon, gentamicin sulfate, sodium metabisulfite, polyethylene glycol, acetic acid-sodium acetate buffer solution, and glucose solution into 650ml of water for injection to dissolve; Adjust the pH value to 6.5, and add water for injection to 1000ml.

Embodiment 3

[0021] An injection for preventing and treating porcine viral diseases, containing 100 g of thymopentin and 10×10 gamma interferon in every 1000 ml of the injection 8 IU, gentamicin sulfate 10 million units, sodium thiosulfate 2g, glycine 0.4g, 50mmol / l disodium hydrogen phosphate-sodium dihydrogen phosphate buffer 100ml, 6% (m / v) mannitol 80ml, pH regulator and the remainder of water for injection.

[0022] Take each raw material during preparation, then add thymopentin, gamma interferon, gentamicin sulfate, sodium thiosulfate, glycine, disodium hydrogen phosphate-sodium dihydrogen phosphate buffer, and mannitol into 700ml of water for injection to dissolve; Adjust the pH value to 7.0 with sodium hydroxide, and add water for injection to 1000ml.

[0023] In March 2008, 1,000 pigs were fattened in a pig farm, and about 80 pigs developed symptoms such as coughing, runny nose, fever, depression, loss of appetite, cyanosis in the ears and abdomen, and neurological symptoms in th...

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Abstract

The invention belongs to the technical field of veterinary medicine, specifically to an injection for preventing and treating porcine viral diseases and a preparation method thereof. Every 1000ml of the injection contains 1 to 100g of thymopoietin, 1 to 10*10 <8> IU of interferon, 10 to 50 million units of gentamycin sulfate, 0.1 to 2g of antioxidant, 0.2 to 0.4g of protective agent, 50 to 100ml of buffer, 20 to 80ml of osmotic pressure adjusting agent, a pH adjusting agent and the balance of water for injection. The preparation in the invention is wide in application, fast in curative effect, little in medicine dosage, low in cost, and difficult to bring germ contamination. The injection reduces the stress reaction caused by capturing the animal for many times in injecting, and overcomesthe shortcoming that the water needle made of thymopoietin and interferon is unstable.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and in particular relates to an injection for preventing and treating porcine viral diseases and a preparation method thereof. Background technique [0002] Porcine viral disease is currently an infectious disease that seriously restricts the healthy development of the pig industry. Every year, hundreds of millions of pigs in the country suffer from viral diseases in different seasons, such as porcine epidemic diarrhea and swine fever, especially in recent years. Pig blue ear disease. Once the pigs are infected, the onset is acute, the clinical symptoms are severe, and the virus spreads rapidly, resulting in large-scale deaths and huge economic losses to the breeding industry. What's more serious is that animals are in close contact with humans, and some zoonotic diseases also pose potential threats to human health. Viral infectious diseases are usually prevented by vaccination, but on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/21A61K9/08A61P31/12A61P31/04A61K38/08A61K31/7036
Inventor 李明魁姚静张遂平邵艳华郭彦磊王黎明
Owner 河南亚卫动物药业有限公司
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