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Low-molecular citrus pectin capable of being combined with clinical common chemotherapeutic drug for controlling cancer and cancer metastasis and diffusion

A low-molecular-weight, chemotherapeutic drug technology, which is applied in the application field of low-molecular-weight citrus pectin for the preparation of medicines, food or health products, and can solve the problems that low-molecular-weight citrus pectin has not been publicly reported.

Inactive Publication Date: 2011-06-08
范晓青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there are no published reports on the application of low molecular weight citrus pectin to control cancer and metastatic spread.

Method used

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  • Low-molecular citrus pectin capable of being combined with clinical common chemotherapeutic drug for controlling cancer and cancer metastasis and diffusion
  • Low-molecular citrus pectin capable of being combined with clinical common chemotherapeutic drug for controlling cancer and cancer metastasis and diffusion
  • Low-molecular citrus pectin capable of being combined with clinical common chemotherapeutic drug for controlling cancer and cancer metastasis and diffusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Colon cancer is a common malignant tumor, and cell metastasis is an important feature of malignant tumors, and the liver is the most frequently involved organ in colon cancer metastasis. In addition to surgical treatment, medical treatment plays an important role in the treatment of colon cancer. However, judging from the current clinical treatment effect, drug resistance and toxic side effects of commonly used chemotherapeutic drugs have become a difficult problem in the treatment of colon cancer.

[0026] The growth and metastasis of colon cancer is a complex process: it is related to abnormal cell differentiation, abnormal proliferation, abnormal growth, biological characteristics of cancer cells, immune status of the body and the microenvironment of the liver. Each step involves a variety of molecular events. Knowledge of these molecular events will provide a theoretical basis for the prevention and treatment of colon cancer and its liver metastases. In these mecha...

Embodiment 2

[0079] LCP-inhibitory effect on mouse liver cancer H22 tumor strain, CY is cyclophosphamide.

[0080]

[0081] During the experiment, the mice in each group had normal drinking water, coat color and activity status. Five days after the mice were inoculated with H22 cells, subcutaneous tumors could be touched in each group, and the activity status of the mice in the LCP-administered groups was normal during the test. Animals were sacrificed on the 10th day, and it was found during anatomy that, compared with NS group, the tumor infiltration range of each LCP group was smaller, the depth was limited, and the tumor body was easily peeled off. The tumor inhibition rate of combined application of LCP and CY was significantly higher than that of each group, with statistical significance (P<0.001). There was no significant difference in body weight of mice in LCP group compared with NS group, and the body weight of mice in single CY group was significantly lower than that of NS gr...

Embodiment 3

[0084] LCP-inhibitory effect on mouse cervical cancer U14 tumor strain, DOX is doxorubicin.

[0085]

[0086] During the experiment, the mice in each group had normal drinking water, coat color and activity status. The mice were inoculated with U14 cells for 8 days, and the animals were sacrificed 10 days after administration, and the tumor inhibition rate was calculated by dissection. Compared with the NS group, the tumor infiltration range of the LCP groups was smaller, the depth was limited, and the tumors were easy to peel off. The tumor inhibition rate of combined application of LCP and DOX was significantly higher than that of each group, which was statistically significant (P<0.01).

[0087] The experimental results showed that the inhibitory effect of LCP on tumor growth was dose-dependent, and the tumor inhibition rate of combined application of LCP and DOX was significantly higher than that of each group, which was statistically significant (P<0.01).

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Abstract

The invention relates to a new application of a low-molecular citrus pectin, in particular to an application of a low-molecular citrus pectin for preparing drugs, foods or health products. The drugs, foods or health products are used for being combined with a clinical common chemotherapeutic drug for controlling cancer and cancer metastasis and diffusion. The low-molecular citrus pectin and the clinical common chemotherapeutic drug are combined for controlling cancer and cancer metastasis and diffusion, wherein the cancer is colon cancer, liver cancer or cervical cancer; and the clinical common chemotherapeutic drug is PAC-1, cyclophosphamide or adriamycin.

Description

technical field [0001] The present invention relates to a new application of low-molecular-weight citrus pectin, in particular to the application of low-molecular-weight citrus pectin for the preparation of medicines, food or health products, and the medicines, food or health products are used in combination with commonly used clinical chemotherapy drugs for Controls the metastatic spread of cancer and cancer. Background technique [0002] Natural citrus pectin is a polysaccharide complex (long-chain carbohydrate) and a dietary fiber. It is obtained from the peel and pulp of natural citrus fruits such as lemons, grapefruits, oranges and tangerines. The long-chain product of this polysaccharide has many branches and has the function of adhesion. Natural pectin is a soluble fiber that cannot be absorbed by the intestine after consumption. Although some are fermented in the large intestine, natural citrus pectin is generally not very effective for the human body. [0003] L...

Claims

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Application Information

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IPC IPC(8): A61K31/732A61K45/00A61P35/00A61P1/00A61P1/16A61P15/00A23L1/29A61K31/704A61K31/664A61K31/495A23L33/00
Inventor 范晓青许鹏刘海鹰俞仲华
Owner 范晓青
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