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Photoacoustic component resolution imaging method and device based on spectral encoding

An imaging method and coding technology, which are applied in the field of spectral coding photoacoustic imaging devices, can solve the problems that the concentration and distribution of the constituent elements of the mixture cannot be reflected well, and achieve the effect of getting rid of inaccurate images.

Active Publication Date: 2012-10-03
SOUTH CHINA NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the problems that the prior art cannot reflect the concentration and distribution of the components of the mixture well, to establish a photoacoustic component analytical imaging method based on spectral coding, and to quantitatively analyze the components of the photoacoustic imaging hybrid system method

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  • Photoacoustic component resolution imaging method and device based on spectral encoding
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  • Photoacoustic component resolution imaging method and device based on spectral encoding

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Embodiment 1

[0059] Embodiment 1 Device of the present invention

[0060] figure 1 It is a schematic diagram of the structure of the device of the present invention. The device of the present invention includes an excitation light source component, a signal collection component, and a computer component, and the above components are electrically connected in sequence. The LABVIEW acquisition program controls each component to realize the following workflow. While the excitation light component outputs laser pulses, it simultaneously outputs a trigger signal, which drives the acquisition component to collect photoacoustic signals. The collected photoacoustic signals are transmitted to the computer component for real-time recording. After completion, drive the stepper motor to rotate a certain angle for the next collection. Among them, the pulsed laser beam emitted by the tunable laser 1-1 in the excitation light source component is divided into two beams at the beam splitter 1-2 (the refle...

Embodiment 3

[0063] In Example 3, the photoacoustic image of the dye-pigment mixed system obtained in Example 2 is processed by using the quantitative analysis algorithm of the mixed system elements.

[0064] The photoacoustic image is processed by the quantitative analysis algorithm of the elements of the mixed system, and the absorption spectra of the three elements in the mixed system are measured by a spectrophotometer in advance, and the extinction coefficient spectrum is obtained by calculation, such as figure 2 As shown in (b), then calculate the extinction coefficients of the three elements at 532nm, 750nm and 800nm ​​(in this example, indocyanine green 1818&64325&80270, heme 41307.2&507.9&821.7, methylene blue 7466.9&860.2&1299.4 ), assign the value to the corresponding position of the algorithm, and then use the algorithm to solve the two photoacoustic images point by point, and finally get the concentration distribution of the three elements at each point, and express it in the ...

Embodiment 5

[0067] Example 5 The photoacoustic image of the mixed system of biological tissues obtained in Example 4 is processed by applying the quantitative analysis algorithm of the elements of the mixed system.

[0068] The photoacoustic image is processed by the quantitative analysis algorithm of the elements of the mixed system, and the absorption spectrum of the two elements in the mixed system is measured by a spectrophotometer in advance, and the extinction coefficient spectrum is obtained by calculation, such as Figure 4 As shown in (b), then calculate the extinction coefficients of the two elements at 1064nm and 532nm (in this example, blood 0.393&0.976, muscle 0.2384&0.143), assign them to the corresponding positions of the algorithm, and then use the algorithm to compare the two A photoacoustic image is solved point by point, and finally the concentration distribution of the two elements at each point is obtained, and it is expressed in the form of an image, such as Figure ...

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Abstract

The invention discloses a photoacoustic component resolution imaging method based on spectral encoding. The method comprises the following steps: uniform pulsed laser beams excite a sample; the sample absorbing the light energy to generate photoacoustic signals; a signal collection system synchronously collects the photoacoustic signals until the first collection process is completed; changes thewavelength, and collects the photoacoustic signals for the second time; images are reconstructed by a MATLAB program after the second signal collection process is completed; and the reconstructed images are reprocessed by a quantitative analysis algorithm for analyzing the components of a mixed system to obtain the spatial distribution graph of single component concentration. The device comprisesan excitation light source assembly, a signal collection assembly, a computer assembly, a coupling tank and a step motor. In the method, the concentration information of a single component spatial distribution can be extracted from the photoacoustic image, which has the great meaning in the nondestructive disease diagnosis field. In addition, the spectral encoding photoacoustic imaging device disclosed in the invention has simple structure, and is convenient in operation and easy to implement.

Description

technical field [0001] The invention belongs to the technical field of photoacoustic imaging, and in particular relates to a method for quantitatively analyzing components of a mixing system by using spectrally encoded photoacoustic imaging and a spectrally encoded photoacoustic imaging device. Background technique [0002] Photoacoustic imaging is an emerging technology based on photoacoustic principles and ultrasonic imaging. It has developed rapidly in recent years, such as electronic circuit detection, liquid flow measurement, and life sciences. The nanosecond-level laser pulse is irradiated on the substance and absorbed, and the thermal expansion in a short period of time generates an ultrasonic signal. The intensity of the signal is related to the absorption of the substance and the intensity of the excitation light. Different substances have different light absorption capabilities. When the light intensity is uniform and stable, the intensity of light and shade on the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/17
Inventor 邢达张建杨思华
Owner SOUTH CHINA NORMAL UNIVERSITY