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Application of snow saussurea and snow saussurea extract in preparation of anti-hypoxia medicaments and method for preparing snow saussurea extract

An anti-hypoxic drug, extract technology, applied in the field of medicine

Active Publication Date: 2011-06-29
中国人民解放军联勤保障部队第九四〇医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, domestic research on the pharmacology of Snow Lotus mainly focuses on improving the body's immunity, expelling wind and dampness, and terminating pregnancy, while there are few studies on its anti-hypoxia effect. No report

Method used

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  • Application of snow saussurea and snow saussurea extract in preparation of anti-hypoxia medicaments and method for preparing snow saussurea extract
  • Application of snow saussurea and snow saussurea extract in preparation of anti-hypoxia medicaments and method for preparing snow saussurea extract
  • Application of snow saussurea and snow saussurea extract in preparation of anti-hypoxia medicaments and method for preparing snow saussurea extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] ①Take the dried snow lotus, crush it, add 13 times the amount of ethanol solution with a volume concentration of 50%, warm soak and extract at 50°C, filter the extract, concentrate under reduced pressure to a specific gravity of about 1.40g / ml, and obtain the alcohol extract;

[0086] ② Disperse the extract with 3 times the amount of water to obtain a water dispersion system, sequentially extract 3 times with petroleum ether, ethyl acetate and n-butanol equivalent to 1 / 2 volume of the water dispersion system, and combine the petroleum ether, ethyl acetate and n-butanol after multiple extractions respectively. Ethyl acetate and n-butanol extracts were concentrated under reduced pressure and freeze-dried to obtain petroleum ether, ethyl acetate and n-butanol fractions respectively;

Embodiment 2

[0088] ①Use 13 times the amount of ethanol solution with a volume concentration of 0.01-95% to extract the dried and crushed snow lotus at 20-70°C, filter and concentrate to extract; ②Use 15 times the amount and the temperature is 60°C Dissolve the above-mentioned extract in hot water, cool and filter to remove the fat-soluble components to obtain the extract; ③ Slowly flow the extract through the macroporous resin column that has been eluted with ethanol; ④ Rinse the above-mentioned macroporous resin column with distilled water first , and then wash the macroporous resin column with an ethanol solution with a volume concentration of 80%, collect the ethanol eluate, concentrate under reduced pressure, and dry in vacuum to obtain Saussurea sauraceae extract.

[0089] The warm soaking extraction described in step ① can be repeated 3 times.

[0090] In step ③, after the extract flows through the polyamide column, the polyamide column is rinsed with distilled water, and the eluent...

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Abstract

The invention discloses application of snow saussurea and snow saussurea extract in preparation of anti-hypoxia medicaments and a method for preparing snow saussurea extract. The snow saussurea is one of saussurea involucrate, saussurea medusa and saussurea obvallata; the snow saussurea extract is one of saussurea involucrate extract, saussurea medusa extract and saussurea obvallata extract; and the snow saussurea extract is aqueous extract or ethanol extract of the snow saussurea and anti-hypoxia active ingredients extracted from the snow saussurea by a system solvent method and a macroporous adsorptive resin method. Tests find and prove that the anti-hypoxia medicaments prepared by the snow saussurea and the snow saussurea extract have obvious anti-hypoxia effect; moreover, the preparation method is simple, and the active ingredients of the snow saussurea can be effectively extracted.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the application of snow lotus crude drug powder and snow lotus extract in pharmacy. Background technique [0002] my country is the country with the most extensive plateau area, the largest population and the longest plateau border in the world. The unique low-pressure and hypoxic environment of the plateau causes people who first arrive at the plateau to be affected by the hypoxic environment, and have symptoms of acute mountain sickness such as dizziness, chest tightness, nausea and vomiting, insomnia, and memory loss. With the increasing economic development of the western plateau and the needs of military struggle, more and more people will enter the plateau, but the plateau hypoxia seriously affects people's health and work ability, and even endangers their lives. In addition, in response to natural disasters such as earthquakes in plateau areas, altitude sickness will serio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/285A61P39/00
Inventor 贾正平马慧萍樊鹏程景临林
Owner 中国人民解放军联勤保障部队第九四〇医院
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