Cefcapene pivoxil hydrochloride composition and preparation method thereof

Abstract

The invention relates to a cefcapene pivoxil hydrochloride composition and a preparation method thereof. The composition comprises a tablet core and a coating layer, wherein the tablet core comprises cefcapene pivoxil hydrochloride, a filler, a disintegrating agent, an antisticking agent and a lubricating agent; the particle size of the raw material of cefcapene pivoxil hydrochloride is smaller than 100 microns; the antisticking agent accounts for 2%-10% in percentage by weight of the tablet core; the filter comprises a filler such as starch and the like and soluble auxiliary materials; and the soluble auxiliary materials accounts for 1%-10% in percentage by weight of the tablet core. The prepared cefcapene pivoxil hydrochloride tablet has good disintegration, and the dissolution of the cefcapene pivoxil hydrochloride tablet reaches over 75%.

Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefcapene hydrochloride composition and a preparation method thereof. Background technique

[0002] Cefcapene pivoxil hydrochloride (cefcapene pivoxil hydrochloride), its chemical name is (6R, 7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-pentenylamino]-3 -[(aminocarbonyl)oxy]methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl Oxypropoxymethyl) ester hydrochloride monohydrate is an oral broad-spectrum antibiotic with valproyloxymethyl and stable to β-lactamase developed by Shionogi, Japan, in July 1997 It is listed in Japan under the trade name Flomox. It exerts antibacterial effect by blocking the synthesis of bacterial cell walls. It is mainly suitable for respiratory tract infections, otitis media, sinusitis, urinary tract infections, skin and skin tissue infections, and biliary tract infections caused by sensitive bacteria. Tablets are curren...

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