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Production method of water-soluble licoflavone

A technology of licorice flavonoids and production method, which are applied in directions such as pharmaceutical formulations, preparations for skin care, cosmetics, etc., can solve problems such as low solubility, compatibility and application limitations, and achieve the effects of simple operation, simple method and reduced preparation cost.

Inactive Publication Date: 2011-08-03
SHANGHAI OLI ENTERPRISES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The excellent self-beautifying efficacy and safety of licorice flavonoids make it widely used in whitening cosmetics, but because licorice flavonoids are oil-soluble substances, their solubility in aqueous solution is extremely small, and the base materials of most cosmetics are water-based. The oil-soluble properties of flavonoids make their compatibility and application in cosmetics still subject to relatively large limitations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] In a 500mL reaction flask with a stirring and heating reflux device, first add 250g of absolute ethanol and 50g of licorice flavonoids with a purity of 40%, stir to dissolve all the licorice flavonoids, then slowly add 400g of β-cyclodextrin, and the internal temperature rises to 50°C , and stirred for 1 hour. Make cyclodextrin fully include licorice flavonoids. Then dry at 70-80°C under a vacuum condition of -0.09MPa, steam until the clathrate has no ethanol smell, and obtain a reddish-yellow, dry clathrate. The inclusion compound was dissolved in 750 g of deionized water and fully stirred for about 1 hour, filtered, the filtrate was collected, and distilled to a water-soluble flavonoid with a concentration of licorice flavonoids of 2.0% and a reddish-brown color.

Embodiment 2

[0017] In a 500mL reaction flask with a stirring and heating reflux device, first add 250g of absolute ethanol and 50g of licorice flavonoids with a purity of 92%, stir to completely dissolve the licorice flavonoids, then slowly add 200g of β-cyclodextrin, and stir at room temperature for 1 hour. Make cyclodextrin fully include licorice flavonoids. Then dry it at 70-80°C under the condition of vacuum -0.07Pa, steam until the clathrate has no ethanol smell, and obtain a yellow, dry clathrate. Dissolve the inclusion compound in 750 g of deionized water and stir well for about 1 hour, filter, collect the filtrate, and distill to a water-soluble flavonoid with a concentration of licorice flavonoids of 7% and a light yellow color.

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Abstract

The invention relates to a preparation method of water-soluble licoflavone, in particular to a novel method for embedding cyclodextrin into licoflavone. By adopting the method disclosed by the invention, the solubility of licoflavone in water is enhanced, and the application range of licoflavone in whitening and speckle-removing functional cosmetics is expanded.

Description

Technical field: [0001] The invention relates to a production method of water-soluble licorice flavonoids. Through the method of the invention, the solubility of the licorice flavonoid in water is increased, and the application of the licorice flavonoid in functional cosmetics for whitening and removing spots is expanded. Background technique: [0002] Licorice flavonoids are natural compounds extracted from licorice. Licorice flavonoids have many functions in beauty cosmetics. Licorice flavonoids have the effect of inhibiting tyrosinase activity, scavenging oxygen free radicals, and inhibiting the interconversion of dopachrome and the activity of DHICA oxidase. Its antioxidant capacity is closer to that of vitamin E. It has the ability to scavenge oxygen free radicals similar to superoxide dismutase (SOD), and has fast, efficient and safe whitening and spot-removing functions. Its whitening function is superior to other synthetic whitening compounds such as arbutin. Li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/16A61K8/73A61K8/49A61K8/60A61Q19/02
Inventor 崔照云江志洁姚卫
Owner SHANGHAI OLI ENTERPRISES CO LTD
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