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Finasteride soft capsule and amsulosin hydrochloride capsule compound preparation, used capsule and preparing method

A technology of tamsulosin hydrochloride capsules and tamsulosin hydrochloride, applied in the field of medicine, can solve the problems of slow absorption, poor stability, inability to cure the root cause and the like, and achieve the effect of convenient administration

Active Publication Date: 2013-03-20
王致中
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tamsulosin is an α-receptor blocker, which can effectively and quickly relax the smooth muscle of the bladder and prostate, and solve the obstruction of the bladder outlet and posterior urethra, but it can only treat the symptoms, not the root cause
At present, the combination of the two drugs has poor stability and slow absorption

Method used

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  • Finasteride soft capsule and amsulosin hydrochloride capsule compound preparation, used capsule and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Finasteride and Tamsulosin Hydrochloride Capsules (1 mg of finasteride and 0.2 mg of tamsulosin hydrochloride)

[0016] prescription:

[0017] Finasteride soft capsule shell prescription: gelatin 50g, glycerin 23g, water 46g, ethylparaben 0.1g.

[0018] Finasteride Softgel Contents Prescription: Finasteride: 1mg

[0019] PEG400: 80mg

[0020] Propylene glycol: 20mg

[0021] Tamsulosin Hydrochloride Capsules Prescription:

[0022] components

Dosage

Tamsulosin Hydrochloride

0.2g

microcrystalline cellulose

90g

80% ethanol

Appropriate amount

Magnesium stearate

3g

[0023] Preparation:

[0024] Mix gelatin, ethylparaben and water evenly and put them in a container for swelling, add glycerin, heat in a water bath at 70°C until completely dissolved, and then vacuumize and degas at a temperature of about 50°C until there are almost no bubbles...

Embodiment 2

[0025] Example 2 Finasteride and Tamsulosin Hydrochloride Capsules (Finasteride 1mg and Salt Tamsulosin 0.4mg / capsule)

[0026] prescription:

[0027] Finasteride soft capsule shell prescription: gelatin 50g, glycerin 23g, water 46g, ethylparaben 0.1g.

[0028] Finasteride Softgel Contents Prescription: Finasteride: 1mg

[0029] PEG400: 80mg

[0030] Propylene glycol: 20mg

[0031] Tamsulosin Hydrochloride Capsules Prescription:

[0032] components

Dosage

Tamsulosin Hydrochloride

0.4g

microcrystalline cellulose

90g

80% ethanol

Appropriate amount

Magnesium stearate

3g

[0033] Preparation:

[0034] Mix gelatin, ethylparaben and water evenly and put them in a container for swelling, add glycerin, heat in a water bath at 70°C until completely dissolved, and then vacuumize and degas at a temperature of about 50°C until there are almost no bubbles to obtai...

Embodiment 3

[0035] Example 3 Finasteride and Tamsulosin Hydrochloride Capsules (Finasteride 2.5mg and Salt Tamsulosin 0.1mg / capsule)

[0036] prescription:

[0037] Finasteride soft capsule shell prescription: gelatin 50g, glycerin 23g, water 46g, ethylparaben 0.1g.

[0038] Finasteride Softgel Contents Prescription: Finasteride: 2.5mg

[0039] PEG400: 160mg

[0040] Propylene glycol: 40mg

[0041] Tamsulosin Hydrochloride Capsules Prescription:

[0042] components

Dosage

Tamsulosin Hydrochloride

0.1g

microcrystalline cellulose

90g

80% ethanol

Appropriate amount

Magnesium stearate

3g

[0043] Preparation:

[0044] Mix gelatin, ethylparaben and water evenly and put them in a container for swelling, add glycerin, heat in a water bath at 70°C until completely dissolved, and then vacuumize and degas at a temperature of about 50°C until there are almost no bubbles to ...

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Abstract

The invention provides finasteride soft capsule and amsulosin hydrochloride capsule compound preparation; the soft capsule prepared by the finasteride as active components is packaged into hard capsule prepared by the amsulosin hydrochloride as the active components so as to form pharmaceutical composition. The capsule used by the pharmaceutical composition is the capsule prepared by filling the soft capsule prepared by a medicine in the hard capsule of other medicines. The method for preparing the pharmaceutical composition comprises the following steps: encapsulating the finasteride medical liquid into the capsule skin to prepare the soft capsule; preparing the amsulosin hydrochloride into particles or powder, filling the particles or powder in a hard capsule shell, and packing the small finasteride soft capsule into the hard capsule so as to obtain the finished medicine. According to the invention, the soft capsule is added into the hard capsule for combining the finasteride with the amsulosin hydrochloride; the medicine is featured by convenient taking; moreover, the medicine is good in stability and fast in absorption.

Description

technical field [0001] The invention relates to a pharmaceutical composition formed by filling a soft capsule made of finasteride as an active ingredient into a hard capsule made of tamsulosin hydrochloride as an active ingredient, a preparation method and an application thereof, belonging to medicine technology field. Background technique [0002] Benign prostatic hyperplasia (BPH) is one of the common and frequently occurring male senile diseases. According to statistics, the incidence rate of BPH in elderly men over 50 years old is about 30% to 50%, 70% for those aged 70 to 79, and over 90% for those over 80 years old. Because benign prostatic hyperplasia narrows the urethra and causes voiding disorders, BPH is the main cause of urgency, frequency, and dysuria in older men. These symptoms seriously affect the quality of life of the patient, and if not treated in time, it will lead to many serious complications (such as acute urinary retention, stones, renal insufficienc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61K31/18A61K9/48A61P13/08
Inventor 王致中孟祥军
Owner 王致中