Synthesis method of chitosan/polyvinyl alcohol foam

A technology of polyvinyl alcohol and synthesis method, which is applied in the field of medical materials, can solve the problems of unsatisfactory clinical curative effect, etc., and achieve the effect of obvious antibacterial property and enhanced antibacterial strength

Inactive Publication Date: 2011-08-10
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional drainage methods using rubber strips, half pipes, cigarettes, etc. have played a huge role in the treatment and prevention of infection, but the drainage is passive drainage, and the clinical efficacy is not satisfactory; the negative pressure sealing drainage technology created by Dr. Wim Fleischmann utilizes The negative pressure source forms an all-round active drainage, and the drainage effect is a leap forward compared with the traditional drainage method. After being put into clinical practice, it quickly achieved great success.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Chitosan was dissolved in 3wt% dilute acetic acid to prepare a chitosan solution with a mass fraction of 3%. Weigh 10g of PVA and 80ml of distilled water, add them to a vessel equipped with a stirrer and a temperature control device, and heat up to 95°C under stirring at a low speed of 80R / min until the PVA is completely dissolved. Chitosan solution was not added. Cool down to 50°C, add 1.5 ml foaming agent sodium lauryl sulfate, and stir at a high speed of 1000 R / min for 70 minutes to make the solution foam freely to 2.5 times the original volume. Add 8ml of sulfuric acid with a mass fraction of 50%, and continue stirring at high speed for 20min. Add 10 ml of formaldehyde solution with a mass fraction of 36%, and stir at high speed for 20 min. Immediately inject the foam into the mold, put it in an oven, and cure it at a constant temperature of 55-60°C for 6 hours, take out the formed foam, wash away the unreacted formaldehyde solution and sulfuric acid, and wash it ...

Embodiment 2

[0017] Chitosan was dissolved in 3wt% dilute acetic acid to prepare a chitosan solution with a mass fraction of 3%. Weigh 10g of PVA and 80ml of distilled water, add them into a vessel equipped with a stirrer and a temperature control device, and raise the temperature to 95°C under stirring at a low speed of 60R / min until the PVA is completely dissolved. Add the chitosan solution of 20g, continue to stir at a low speed evenly. Cool down to 50°C, add 1.5 ml foaming agent sodium lauryl sulfate, and stir at a high speed of 800 R / min for 70 min to make the solution foam freely to 2.5 times the original volume. Add 8ml of sulfuric acid with a mass fraction of 40%, and stir at high speed for 20min. Add 10 ml of formaldehyde solution with a mass fraction of 36%, and stir at high speed for 20 min. Immediately inject the foam into the mold, put it in an oven, and cure it at a constant temperature of 55-60°C for 6 hours, take out the formed foam, wash away the unreacted formaldehyde s...

Embodiment 3

[0019] Chitosan was dissolved in 3wt% dilute acetic acid to prepare a chitosan solution with a mass fraction of 3%. Weigh 10g of PVA and 80ml of distilled water, add them to a vessel equipped with a stirrer and a temperature control device, and heat up to 95°C under stirring at a low speed of 80R / min until the PVA is completely dissolved. Add the chitosan solution of 40g respectively, continue stirring at a low speed evenly. Cool down to 50°C, add 1.5 ml foaming agent sodium lauryl sulfate, and stir at a high speed of 1000 R / min for 70 minutes to make the solution foam freely to 2.5 times the original volume. Add 8ml of sulfuric acid with a mass fraction of 50%, and continue stirring at high speed for 20min. Add 10 ml of formaldehyde solution with a mass fraction of 36%, and stir at high speed for 20 min. Immediately inject the foam into the mold, put it in an oven, and cure it at a constant temperature of 55-60°C for 6 hours, take out the formed foam, wash away the unreacte...

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Abstract

The invention belongs to field of medical materials and discloses a synthesis method of chitosan/polyvinyl alcohol foam. The synthesis method comprises the following steps: dissolving polyvinyl alcohol to prepare a solution, and adding a chitosan solution into the solution; adding a foaming agent, namely 1-2ml/10g of polyvinyl alcohol, and stirring to ensure that the solution foams freely until the volume is 2.0-2.5 times of the original volume; adding sulfuric acid, stirring for 20-40 minutes continuously, then adding formaldehyde while keeping the temperature not more than 40 DEG C, and stirring for 15-30 minutes; and injecting foams in a mould, curing and forming at 55-60 DEG C, and then washing to ensure that the product is neutral and no foam is generated, thus obtaining the chitosan/polyvinyl alcohol composite foam material. The pure polyvinyl alcohol foam material has no bactriostasis; and the foam material combined with chitosan has obvious antibacterial property, and the antibacterial intensity of the material increases along with the increase of the chitosan content.

Description

technical field [0001] The invention relates to a synthesis method of chitosan / polyvinyl alcohol foam, which belongs to the field of medical materials. technical background [0002] Surgical infection is the most common in the field of surgery, accounting for about 1 / 3 to 1 / 2 of all surgical diseases. Drainage plays an extremely important role in the treatment of surgical infection, and it is possible without antibiotics but absolutely without effective drainage. Appropriate application of drainage can prevent the occurrence or spread of infection, and poor drainage will increase the chance of infection or other complications. Drainage material is the bottleneck of surgical drainage, which directly restricts the effect of drainage in the affected area. Traditional drainage methods using rubber strips, half pipes, cigarettes, etc. have played a huge role in the treatment and prevention of infection, but the drainage is passive drainage, and the clinical efficacy is not sati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/04C08L29/14C08L5/08A61L31/06
Inventor 喻爱喜祝少博
Owner WUHAN UNIV
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