Local injection-type carboplatin microspheres and method for preparing same

Abstract

The invention relates to carboplatin microspheres for local injection and a method or preparing the same. The preparation is the microspheres which are formed by carboplatin and biologically degradable materials and can slowly release carboplatin in human tissues. The preparation method comprises the following steps of: suspending carboplatin crystals in a proper amount of organic solution of biologically degradable materials to prepare suspension; at room temperature, dropwise adding the suspension into mineral oil solution while stirring for emulsion; volatilizing, cleaning and solidifying the emulsified solution, and filtering to obtain carboplatin microspheres; washing the filtered carboplatin microspheres by using ultra pure water and performing decompression drying; and screening the microspheres with the grain size suitable for injection by using a medicinal screen, and collecting the microspheres for later use. The preparation can be used for tumor injection, locally form a sustained high-drug concentration zone in tumors and act on tumor cells for a long time, but cause a lower side effect on other normal cells.

Description

technical field [0001] The invention belongs to a novel pharmaceutical preparation, in particular to a carboplatin microsphere for local injection and a preparation method thereof. Background technique [0002] Many neoplastic diseases such as cancer are common diseases that seriously threaten human life and health, and chemotherapy is one of the most commonly used treatment methods. However, anticancer drugs usually have no specific selectivity for tumor cells and normal somatic cells, and the concentration of drugs accumulated in the local tumor after treatment by the commonly used systemic administration method is low, and the toxic and side effects are obvious, which limits the use of large doses of chemotherapy drugs. poor clinical efficacy. [0003] Ultrasound-guided local tumor chemotherapy is to inject chemotherapy drugs directly into the tumor under the guidance of real-time ultrasound. This method can make the chemotherapeutic drugs act on the tumor area and dire...

AI Technical Summary

Problems solved by technology

However, its shortcoming is that anticancer drugs infiltrate and metabolize with the tissue space, it is difficult to form a durable high-density area of ​​drugs in the target area, and the effect of complete inactivation of cancerous tumor tissue cannot be achieved, and the potential of drug chemotherapy cannot be fully exerted.

This not only fails to achieve the chemotherapy effect expected by doctors and patients, but also brings a lot of pain to patients after repeated chemotherapy for a long time