Artificial biologic valve gradient immersed chemical modification device

Abstract

The invention discloses an artificial biologic valve gradient immersed chemical modification device, which comprises a multi-stage reaction solution container, a clamp, a moving device, a rotary hanger, a machine frame and a motor. The multi-stage reaction solution container comprises a plurality of reaction solution container for accommodating different modifier solutions for chemical modification of an artificial biologic valve; the clamp clamps the artificial biologic valve and fixes the artificial biologic valve in the rotary hanger, and the rotary hanger is arranged on the moving device and can be controlled to rotate to immerse the artificial biologic valve in the different modifier solutions; the moving device is supported by the machine frame and can be controlled to move vertically to immerse different parts of the artificial biologic valve in the modifier solution; and the motor is fixed on the machine frame to provide power for the moving device and the rotary hanger. The device performs multi-stage modification of the artificial biologic valve by using a gradient immersed chemical modification method and realizes the continuous operation of the modification of the artificial biologic valve. In the artificial biologic valve prepared by the device, the inter-molecule crosslinking point distribution is reasonable, and the interval flexibility and edge rigidity are high.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a device for chemically modifying artificial biological valves. Background technique [0002] During the preparation of bioprosthetic valves, the chemical modification of pericardial materials affects the maximum tension, elongation at break, and elastic modulus of bioprosthetic valves. The strength of pericardial material is directly related to the framework of collagen fibers, and the strength of bovine pericardium is anisotropic due to the diversity of crosslinking points of collagen fibers. Therefore, it is very critical to effectively control the collagen fiber cross-linking point of the pericardial material. During the preparation of bioprosthetic valves, the calcification morphology, distribution of calcification areas and calcification rate are different when the pericardial material is implanted in the body. The hydrophobicity of the pericardial material also has a stron...

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Problems solved by technology

[0005] However, the fully submerged chemically modified artificial biological valve (such as pericardial material) process in the prior art has the problem of excessive modification, which cannot well regulate the diversity of collagen fiber crosslinking points of the pericardial material, and cannot make The mechanical strength and flexibility of the pericardial material can be well balanced, and the calcification of the artificial biological valve cannot be prevented

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