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Method for extracting flavone by using surfactant from herb to coordinate with enzymolysis-microwave

A technology of surfactants and herbal plants, applied in the field of extracting active ingredients, can solve the problems of difficulty in adapting to the requirements of modernization of traditional Chinese medicine, long production cycle, low efficiency, etc., and achieve increased dissolution and exudation capacity, good product quality, and low energy consumption Effect

Inactive Publication Date: 2013-04-10
EAST CHINA UNIV OF SCI & TECH
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  • Description
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AI Technical Summary

Problems solved by technology

[0003] Traditional extraction and separation techniques, such as maceration, percolation, decoction, and Soxhlet extraction, generally have disadvantages such as low efficiency, high energy consumption, multiple processes, and long production cycles, which are difficult to meet the requirements of modernization of traditional Chinese medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Extract total flavonoids from Cortex Morus alba:

[0018] (1) Put 5 g of Morus alba medicinal material with a particle size of 20 mesh into a three-necked flask, add 165 mL of deionized water, cellulase and Tween 60, and stir at 45°C for 45 min;

[0019] The content of cellulase is 0.75g / L, and the content of Tween 60 is 2.0g / L;

[0020] (2) The product obtained in step (1) was extracted by microwave for 2.83 minutes, cooled to room temperature for 5 minutes, shaken up, and filtered under reduced pressure;

[0021] The output power of the microwave oven is 650W and the frequency is 2450MHz

[0022] (3) With the extract obtained in step (2), use ultraviolet spectrophotometry at a wavelength of 510nm to measure the flavonoid content. The ultraviolet spectrophotometer set wavelength is 510nm, and the flavonoid content is 0.206g / L.

Embodiment 2

[0024] Extract the total flavonoids from Eclipta chinensis:

[0025] (1) Put 5 g of Eclipta officinalis medicinal material with a particle size of 10 mesh into a three-necked flask, add 105 mL of deionized water, cellulase, Tween 60, and stir for 90 min at 54°C;

[0026] The content of cellulase is 1.00g / L, and the content of Tween 60 is 2.4g / L;

[0027] (2) The product obtained in step (1) was extracted by microwave for 2.36 minutes, cooled to room temperature for 5 minutes, shaken up, and filtered under reduced pressure;

[0028] The output power of the microwave oven is 650W and the frequency is 2450MHz.

[0029] (3) The flavonoid content of the extract obtained in step (2) was determined by ultraviolet spectrophotometry at a wavelength of 510 nm, and the flavonoid content was 0.657 g / L.

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Abstract

The invention provides a method for extracting flavone by using surfactant from a herb to coordinate with enzymolysis-microwave. The method includes the following steps: (1) stirring and mixing the herb with cellulose, the surfactant and water; (2) putting the mixture obtained in step (1) in a microwave device, conducting microwave extraction for 2.0-3.0min, cooling, decompressing and filtering to acquire filtrate that is solution containing flavone. The method has no over high requirement on the granularity of medicinal materials, evenly heats an extraction object, is high-efficiency and quick, saves solvent consumption and reduces energy consumption. By using the solubilization of the surfactant and the wall breaking function of an enzymic preparation and taking water solution as a substitute for organic solvent, the method is low in cost and small in energy consumption and good in product quality.

Description

technical field [0001] The invention relates to a method for extracting active ingredients from herbs. Background technique [0002] The extraction of active ingredients of traditional Chinese medicine is the most basic and important link in the production of traditional Chinese medicine, and it is also an important topic that researchers of extraction technology pay attention to. Due to the complex composition of herbal medicines in herbs, the content of active ingredients is generally low, such as the active ingredient in Morus alba is only about 3%. [0003] Traditional extraction and separation techniques, such as maceration, percolation, decoction, and Soxhlet extraction, generally have disadvantages such as low efficiency, high energy consumption, multiple processes, and long production cycles, which are difficult to meet the requirements of modernization of traditional Chinese medicine. Therefore, some new extraction and separation technologies have emerged. [0004...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30A61K36/605A61K36/28
Inventor 韩伟马婉婉刘曦骆开荣班颖陈惠丹
Owner EAST CHINA UNIV OF SCI & TECH
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