Photodynamic direct radiation therapy device for cerebral gliomas

Abstract

The invention relates to a photodynamic direct radiation therapy device for cerebral gliomas, which is a photodynamic system for radiating a tumor bed part postoperatively, and belongs to the field of medical equipment. The device mainly comprises a multi-cavity sleeve and a fixed seat, wherein the fixed seat is arranged on the multi-cavity sleeve; an outer drainage tube, a dispersion medium input and output pipe, a semipermeable membrane bearing pipe, a pressure control system, a semipermeable membrane and an optical fiber are integrated and fixed in the multi-cavity sleeve; the dispersion medium input and output pipe and the optical fiber are fixed in the semipermeable membrane bearing pipe, and the front ends of the dispersion medium input and output pipe and the optical fiber are coated in the semipermeable membrane fixed on the end part of the semipermeable membrane bearing pipe; the tail ends of the outer drainage tube and the dispersion medium input and output pipe are connected with an anti-backflow device; the front end of the outer drainage tube has absorbing or spraying function; and the intracranial pressure is monitored by the pressure control system in real time. Thedevice can overcome defects that a brain tissue of the patient is exposed for too long time in an operation, the light-prevention time is long after the operation, an intravenous photosensitizer has negative effect on the whole body and cannot repeatedly applied and the like in the conventional photodynamic therapy scheme.

Description

technical field [0001] A photodynamic direct irradiation treatment device for brain glioma is a photodynamic system for irradiating tumor bed parts after operation, and belongs to the field of medical equipment. Background technique [0002] Photodynamic therapy (PDT) is an effective auxiliary method for the treatment of malignant tumors. It has the characteristics of relatively specific killing of tumor cells, less damage to surrounding normal tissues, and less adverse reactions. The mechanism of photodynamic therapy is that after the photosensitizer is injected into the organism, the photosensitizer can be selectively accumulated in the tumor tissue and retained for a long time, and a high concentration area of ​​the photosensitizer will be formed locally in the residual tumor lesion after surgical resection. After laser irradiation, under aerobic conditions, the photosensitizer can be activated, and a self-chain reaction of photosensitization occurs in the cells to produc...

AI Technical Summary

Problems solved by technology

[0003] Due to the disadvantages of conventional photodynamic therapy, such as long exposure time of brain tissue during operation, long time of avoiding light after operation, systemic side effects after intravenous administration of photosensitizer, and non-repeatable application, etc., photodynamic therapy for glioma has been delayed. cannot be promoted

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