Preparation method of Xinnaoshutong tablet

Abstract

The invention discloses a preparation method of a Xinnaoshutong tablet, comprising the steps of: preparing tribulus terrestris flavone percolate, preparing tribuloside aqueous extract, preparing tribulus terrestris alcohol extract, preparing alcohol extract of tribulus terrestris and water, preparing tribulus terrestris chromatography paste, preparing tribulus terrestris extract particles, preparing the core of the Xinnaoshutong tablet, performing film coating on the core of the Xinnaoshutong tablet and the like. The preparation method of the invention not only solves the problems of integration and extraction of gross saponins of tribulus terrestris, but also provides a solution to the defects of dry tribulus terrestris extract, difficult crushing, great labor intensity and serious dust pollution existing in the prior art of Xinnaoshutong tablet preparation, as well as to the problems of difficult process control during wet granulation, easy absorption of moisture and deterioration, undesirable fluidity, frequent emergence of splinters, fragments, great differences in tablet weight and inferior hardness. The method also has the advantages of simple operation, reliable technology,stable quality and low labor intensity. According to the method, product quality can be improved, production cost is reduced. Thus the method of the invention satisfies the requirements of industrialproduction.

Description

technical field [0001] The present invention relates to a preparation method of Xinnaoshutong Tablets, in particular to a traditional Chinese medicine film-coated tablet containing Tribulus terrestris furostanol saponins and Tribulus terrestris total flavonol glycosides in the extract of Tribulus terrestris——Xinnaoshutong tablet. The preparation method belongs to the technical field of pharmaceutical preparation preparation. Background technique [0002] Tribulus terrestris L., a plant of the family Zygophyllaceae, has a long history of medicinal use in my country. In China, the total saponins of Tribulus terrestris extracted from Tribulus terrestris are used as raw materials, and the oral preparations made and marketed include Xinnaoshutong Capsules and Xinnaoshutong Tablets, etc., which have shown good curative effect in the treatment of cardiovascular and cerebrovascular diseases. Now also someone is researching and developing Xinnaoshutong Oral Dropping Pills (patent ap...

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Problems solved by technology

[0005] The purpose of the present invention is to provide a Tribulus extract that can simultaneously obtain furostanol saponins and total flavonol glycosides of Tribulus and the preparation of this extract conforms to the "Drug Standard for Xinnaoshutong Tablets" (WS-10906 (ZD -0906)-2002) requirements, that is, the preparation method of Xinnaoshutong Tablets in which the furostanol saponin in the Tribulus terrestris extract contained in each tablet is 90.0% to 110.0% of the labeled amount of 15mg, and the total flavonol glycosides are not less than 0.20mg, In order to solve the deficiency of extracting furostanol saponins of Tribulus terrestris and total flavonol glycosides of Tribulus terrestris respectively in the prior art, solve the problem that the thick saponin of Tribulus terrestris is not easy to dry and pulverize at the same time, and the preparation of heart glycosides by wet granulation method in the prior art Naoshutong tablets have technical problems such as difficult granulation, complicated process, high labor intensity, unstable tablet weight, loose tablets, and splits, etc., in order to improve the product qualification rate of Xinnaoshutong tablets and reduce production costs, and meet the The needs of industrial production

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